ArticleJournal of diabetes research2016
Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin.
Article in Journal of diabetes research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Association Between Serum 25(OH)D Concentrations and Glucose-Lipid Metabolism in Women With Gestational Diabetes Mellitus: Analysis of A NHANES 2007-2018.Physiological research · 2026Article
- Review
- TREK-1 in the heart: Potential physiological and pathophysiological roles.Frontiers in physiology · 2022Review
- Mechanisms Linking Vitamin D Deficiency to Impaired Metabolism: An Overview.International journal of endocrinology · 2022Review
- Controlled Decompression Attenuates Compressive Injury following Traumatic Brain Injury via TREK-1-Mediated Inhibition of Necroptosis and Neuroinflammation.Oxidative medicine and cellular longevity · 2021Article
- KScientific reports · 2020Article
- The impact of low mineral content water on cardiac function in diabetic rats: focus on oxidative stress.Molecular and cellular biochemistry · 2020Article
- Signaling Molecules Regulating Pancreatic Endocrine Development from Pluripotent Stem Cell Differentiation.International journal of molecular sciences · 2020Review
- Article
- Role of TREK-1 in Health and Disease, Focus on the Central Nervous System.Frontiers in pharmacology · 2019Review
- Identification and characterization of two zebrafish Twik related potassium channels, Kcnk2a and Kcnk2b.Scientific reports · 2018Article
- Sortilin in Glucose Homeostasis: From Accessory Protein to Key Player?Frontiers in pharmacology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inhibition of the potassium channels TREK-1 by spadin (SPA) is currently thought to be a promising therapeutic target for the treatment of depression. Since these channels are expressed in pancreatic
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.