Evidence map›Paper›PMID 28105409›Full record

ReviewFrontiers in cell and developmental biology2016

Cancer and Thrombosis: The Platelet Perspective.

Claire K S Meikle, Clare A Kelly, Priyanka Garg, Leah M Wuescher, Ramadan A Ali, Randall G Worth

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 124 citations in OpenAlex.

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  15. Pro-Tumorigenic and Thrombotic Activities of Platelets in Lung Cancer.International journal of molecular sciences · 2023
    Review
  16. Development and validation of a [European radiology · 2023
    Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Claire K S MeikleDepartment of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences Toledo, OH, USA.
Clare A KellyDepartment of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences Toledo, OH, USA.
Priyanka GargDepartment of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences Toledo, OH, USA.
Leah M WuescherDepartment of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences Toledo, OH, USA.
Ramadan A AliDepartment of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences Toledo, OH, USA.
Randall G WorthDepartment of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences Toledo, OH, USA.
University of Toledo · US

Funding

In vivo role of platelets in bacterial blood infectionR01HL122401 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI WORTH, RANDALL GLENN · 2014 to 2017
$1.5M
NHLBI NIH HHS R01 HL122401
6 · The paper itself

Abstract

Platelets are critical to hemostatic and immunological function, and are key players in cancer progression, metastasis, and cancer-related thrombosis. Platelets interact with immune cells to stimulate anti-tumor responses and can be activated by immune cells and tumor cells. Platelet activation can lead to complex interactions between platelets and tumor cells. Platelets facilitate cancer progression and metastasis by: (1) forming aggregates with tumor cells; (2) inducing tumor growth, epithelial-mesenchymal transition, and invasion; (3) shielding circulating tumor cells from immune surveillance and killing; (4) facilitating tethering and arrest of circulating tumor cells; and (5) promoting angiogenesis and tumor cell establishment at distant sites. Tumor cell-activated platelets also predispose cancer patients to thrombotic events. Tumor cells and tumor-derived microparticles lead to thrombosis by secreting procoagulant factors, resulting in platelet activation and clotting. Platelets play a critical role in cancer progression and thrombosis, and markers of platelet-tumor cell interaction are candidates as biomarkers for cancer progression and thrombosis risk.

Indexed as

cancermetastasisplateletTCIPAthrombosis

Identifiers

PMID28105409
PMCPMC5214375
OpenAlexW2568572531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.