Evidence map›Paper›PMID 28105386›Full record

ArticleTremor and other hyperkinetic movements (New York, N.Y.)2016

A Comparison Study of Cognitive and Neuropsychiatric Features of Essential Tremor and Parkinson's Disease.

Verónica Puertas-Martín, Alberto Villarejo-Galende, Sara Fernández-Guinea, Juan Pablo Romero, Elan D Louis, Julián Benito-León

Abstract read
In one paragraph

Article in Tremor and other hyperkinetic movements (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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  18. Article
  19. Functional Outcomes of Cerebellar Malformations.Frontiers in cellular neuroscience · 2019
    Review
  20. Essential Tremor and Parkinson's Disease: Exploring the Relationship.Tremor and other hyperkinetic movements (New York, N.Y.) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Verónica Puertas-MartínDepartment of Neurology, University Hospital "12 de Octubre", Madrid, Spain.
Alberto Villarejo-GalendeDepartment of Neurology, University Hospital "12 de Octubre", Madrid, Spain; Department of Medicine, Faculty of Medicine, Complutense University, Madrid, Spain.
Sara Fernández-GuineaDepartment of Basic Psychology II (Cognitive Processes), Faculty of Psychology, Complutense University, Madrid, Spain.
Juan Pablo RomeroFaculty of Biosanitary Sciences, Francisco de Vitoria University, Pozuelo de Alarcón, Madrid, Spain.
Elan D LouisDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA; Center for Neuroepidemiology and Clinical Neurological Research, Yale School of Medicine and Yale School of Public Health, New Haven, CT, USA.
Julián Benito-LeónDepartment of Neurology, University Hospital "12 de Octubre", Madrid, Spain; Department of Medicine, Faculty of Medicine, Complutense University, Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.

Funding

ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMORR01NS039422 · NINDS · YALE UNIVERSITY · PI LOUIS, ELAN D · 2000 to 2013
$7.7M
Identification of Susceptibility Genes for Essential TremorR01NS073872 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLARK, LORRAINE N, LOUIS, ELAN D · 2011 to 2019
$7.4M
Environmental Epidemiology of Essential TremorR01NS094607 · NINDS · YALE UNIVERSITY · PI LOUIS, ELAN D · 2016 to 2020
$3.9M
PATHOLOG-OMICS - ESSENTIAL TREMOR IN THE BROADER CONTEXT OF NEURODEGENERATIONR01NS088257 · NINDS · YALE UNIVERSITY · PI FAUST, PHYLLIS L, LOUIS, ELAN D · 2015 to 2019
$3.3M
in Vivo Quantification of Cerebellar GABA and NAA in Essential TremorR01NS085136 · NINDS · YALE UNIVERSITY · PI MATUSKEY, DAVID A · 2013 to 2017
$3.3M
CNS Plasticity of Human Adipo-derived Multipotent CellsR21NS046346 · NINDS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LEE, KEVIN SCOTT · 2003 to 2004
$361k
NINDS NIH HHS R01 NS039422NINDS NIH HHS R01 NS073872NINDS NIH HHS R01 NS085136NINDS NIH HHS R01 NS088257NINDS NIH HHS R01 NS094607NINDS NIH HHS R21 NS046346
6 · The paper itself

Abstract

backgroundEssential tremor (ET) and Parkinson's disease (PD) are two of the most common movement disorders. Leaving aside their motor features, these two conditions share several non-motor features, including cognitive dysfunction and personality changes. However, there are few data comparing the cognitive and personality profiles of ET with PD. Here we compare the cognitive and personality profiles of the two diseases.

methodsThirty-two consecutive non-demented ET patients (13 females and 19 males) (67.7±9.8 years), 32 non-demented PD patients (13 females and 19 males) (67.7±9.5 years), and 32 healthy matched controls (14 females and 18 males) (67.9±10.1 years) underwent a neuropsychological test battery, including a global cognitive assessment and tests of attention, executive function, memory, language, and visuospatial function, as well as the Personality Assessment Inventory. Multivariable linear regression analyses were performed, adjusted for age, sex, years of education, medications that potentially affect cognitive function, number of medications, and the 17-item Hamilton Depression Rating Scale Total Score.

resultsNeuropsychological scores were similar in PD and ET patients, but patients with disease performed more poorly than control subjects in cognitive tasks such as attention, executive function, memory, and naming. DISCUSSION: ET and PD exhibited similar deficits in specific aspects of neuropsychological functioning, particularly those thought to rely on the integrity of the prefrontal cortex, and this suggests involvement of frontocerebellar circuits. These findings further challenge the traditional view of ET as a benign and monosymptomatic disorder.

Indexed as

cerebellumcognitive impairmentEssential tremormovement disordersneurobehavioral manifestationsneuropsychologyParkinson’s diseasethalamus

Identifiers

PMID28105386
PMCPMC5233783

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.