ArticleACS medicinal chemistry letters2017
Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension.
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Article in ACS medicinal chemistry letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2citing papers in PubMed
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Who cites it
2 citing papers in PubMed.
- Indolyl Azaspiroketal Mannich Bases Are Potent Antimycobacterial Agents with Selective Membrane Permeabilizing Effects and in Vivo Activity.Journal of medicinal chemistry · 2018Article
- N-Aryl-7-hydroxy-5-oxo-2,3-dihydro-1H,5H-pyrido-[3,2,1-ij]quinoline-6-carboxamides. The Synthesis and Effects on Urinary Output.Scientia pharmaceutica · 2018Article
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Authors and funding
28 authors.
Whitney L PetrilliDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Scott B HoytDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Clare LondonDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Daniel McMastersDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Andreas VerrasDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Mary StruthersDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Doris CullyDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Thomas WisniewskiDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Ning RenDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Charlene BoppDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Andrea SokDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Qing ChenDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Ying LiDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Elaine TungDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Wei TangDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Gino SalituroDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Ian KnemeyerDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Bindhu KaranamDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Joseph ClemasDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Gaochao ZhouDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Jack GibsonDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Carrie Ann ShipleyDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Douglas J MacNeilDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Ruth DuffyDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
James R TataDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Feroze UjjainwallaDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Amjad AliDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Yusheng XiongDepartments of Discovery Chemistry, Chemistry Modeling & Informatics, Hypertension, Drug Metabolism & Pharmacokinetics, and In Vitro Pharmacology, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herein we report the discovery and hit-to-lead optimization of a series of spirocyclic piperidine aldosterone synthase (CYP11B2) inhibitors. Compounds from this series display potent CYP11B2 inhibition, good selectivity versus related CYP enzymes, and lead-like physical and pharmacokinetic properties.
Indexed as
aldosterone synthaseCYP11B2hypertension
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