ArticleFrontiers in aging neuroscience2016
Strength of Structural and Functional Frontostriatal Connectivity Predicts Self-Control in the Healthy Elderly.
Article in Frontiers in aging neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- The measurement of self-regulation in the Adolescent Brain Cognitive Development (ABCD) Study.PloS one · 2025Article
- Frontostriatal circuitry and the tryptophan kynurenine pathway in major psychiatric disorders.Psychopharmacology · 2024Article
- Non-Opioid Anesthetics Addiction: A Review of Current Situation and Mechanism.Brain sciences · 2023Review
- Investigating associations of delay discounting with brain structure, working memory, and episodic memory.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Cortical Volume in the Right Cingulate Cortex Mediates the Increase of Self-Control From Young Adult to Middle-Aged.Frontiers in behavioral neuroscience · 2022Article
- Striatal functional connectivity in chronic ketamine users: a pilot study.The American journal of drug and alcohol abuse · 2020Article
- Basal ganglia and thalamic tract connectivity in very preterm and full-term children; associations with 7-year neurodevelopment.Pediatric research · 2020Article
- White matter correlates of temporal discounting in older adults.Brain structure & function · 2018Article
- Increased BOLD Signals in dlPFC Is Associated With Stronger Self-Control in Food-Related Decision-Making.Frontiers in psychiatry · 2018Article
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Self-regulation refers to the successful use of executive functions and initiation of top-down processes to control one's thoughts, behavior, and emotions, and it is crucial to perform self-control. Self-control is needed to overcome impulses and can be assessed by delay of gratification (DoG) and delay discounting (DD) paradigms. In children/adolescents, good DoG/DD ability depends on the maturity of frontostriatal connectivity, and its decline in strength with advancing age might adversely affect self-control because prefrontal brain regions are more prone to normal age-related atrophy than other regions. Here, we aimed at highlighting the relationship between frontostriatal connectivity strength and DoG performance in advanced age. We recruited 40 healthy elderly individuals (mean age 74.0 ± 7.7 years) and assessed the DoG ability using the German version of the DoG test for adults in addition to the delay discounting (DD) paradigm. Based on diffusion-weighted and resting-state functional magnetic resonance imaging data, respectively, the structural and functional whole-brain connectome were reconstructed based on 90 different brain regions of interest in addition to a 12-node frontostriatal DoG-specific network and the resulting connectivity matrices were subjected to network-based statistics. The 90-nodes whole-brain connectome analyses revealed subnetworks significantly associated with DoG and DD with a preponderance of frontostriatal nodes involved suggesting a high specificity of the findings. Structural and functional connectivity strengths between the putamen, caudate nucleus, and nucleus accumbens on the one hand and orbitofrontal, dorsal, and ventral lateral prefrontal cortices on the other hand showed strong positive correlations with DoG and negative correlations with DD corrected for age, sex, intracranial volume, and head motion parameters. These associations cannot be explained by differences in impulsivity and executive functioning. This pattern of correlations between structural or functional frontostriatal connectivity strength and self-control suggests that, in addition to the importance of the frontostriatal nodes itself, the structural and functional properties of different connections within the frontostriatal network are crucial for self-controlled behaviors in the healthy elderly. Because high DoG/low DD is a significant predictor of willpower and wellbeing in the elderly population, interventions aiming at strengthening frontostriatal connectivity to strengthen self-controlled behavior are needed in the future.
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