Evidence map›Paper›PMID 28104989›Full record

ArticleWorld journal of gastroenterology2017

Trefoil factor-3 is not a useful marker of mucosal healing in Crohn's disease treated with anti-TNF-α antibodies.

Piotr Eder, Kamila Stawczyk-Eder, Katarzyna Korybalska, Natasza Czepulis, Joanna Luczak, Liliana Lykowska-Szuber, Iwona Krela-Kazmierczak, Krzysztof Linke, Janusz Witowski

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Piotr EderPiotr Eder, Kamila Stawczyk-Eder, Liliana Lykowska-Szuber, Iwona Krela-Kazmierczak, Krzysztof Linke, Department of Gastroenterology, Human Nutrition and Internal Diseases, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Kamila Stawczyk-EderPiotr Eder, Kamila Stawczyk-Eder, Liliana Lykowska-Szuber, Iwona Krela-Kazmierczak, Krzysztof Linke, Department of Gastroenterology, Human Nutrition and Internal Diseases, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Katarzyna KorybalskaPiotr Eder, Kamila Stawczyk-Eder, Liliana Lykowska-Szuber, Iwona Krela-Kazmierczak, Krzysztof Linke, Department of Gastroenterology, Human Nutrition and Internal Diseases, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Natasza CzepulisPiotr Eder, Kamila Stawczyk-Eder, Liliana Lykowska-Szuber, Iwona Krela-Kazmierczak, Krzysztof Linke, Department of Gastroenterology, Human Nutrition and Internal Diseases, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Joanna LuczakPiotr Eder, Kamila Stawczyk-Eder, Liliana Lykowska-Szuber, Iwona Krela-Kazmierczak, Krzysztof Linke, Department of Gastroenterology, Human Nutrition and Internal Diseases, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Liliana Lykowska-SzuberPiotr Eder, Kamila Stawczyk-Eder, Liliana Lykowska-Szuber, Iwona Krela-Kazmierczak, Krzysztof Linke, Department of Gastroenterology, Human Nutrition and Internal Diseases, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Iwona Krela-KazmierczakPiotr Eder, Kamila Stawczyk-Eder, Liliana Lykowska-Szuber, Iwona Krela-Kazmierczak, Krzysztof Linke, Department of Gastroenterology, Human Nutrition and Internal Diseases, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Krzysztof LinkePiotr Eder, Kamila Stawczyk-Eder, Liliana Lykowska-Szuber, Iwona Krela-Kazmierczak, Krzysztof Linke, Department of Gastroenterology, Human Nutrition and Internal Diseases, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Janusz WitowskiPiotr Eder, Kamila Stawczyk-Eder, Liliana Lykowska-Szuber, Iwona Krela-Kazmierczak, Krzysztof Linke, Department of Gastroenterology, Human Nutrition and Internal Diseases, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Poznan University of Medical Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate whether repeated serum measurements of trefoil factor-3 (TFF-3) can reliably reflect mucosal healing (MH) in Crohn's disease (CD) patients treated with anti-tumor necrosis factor-α (anti-TNF-α) antibodies.

methodsSerum TFF-3 was measured before and after anti-TNF-α induction therapy in 30 CD patients. The results were related to clinical, biochemical and endoscopic parameters. MH was defined as a ≥ 50% decrease in Simple Endoscopic Score for Crohn's disease (SES-CD).

resultsSES-CD correlated significantly with CD clinical activity and several standard biochemical parameters (albumin, leukocyte and platelet counts, C-reactive protein, erythrocyte sedimentation rate, fibrinogen). In contrast, SES-CD did not correlate with TFF-3 (

conclusionSerum TFF-3 is not a convenient and reliable surrogate marker of MH during therapy with TNF-α antagonists in CD.

Indexed as

AdalimumabAdultBiomarkersCrohn DiseaseEndoscopyFecesFemaleGastrointestinal AgentsHumansInduction ChemotherapyInfliximabIntestinal MucosaLeukocyte L1 Antigen ComplexMaleProspective StudiesSeverity of Illness IndexAdalimumabBiomarkersGastrointestinal AgentsInfliximabLeukocyte L1 Antigen ComplexTFF3 protein, humanTrefoil Factor-3Tumor Necrosis Factor-alphaAdalimumabCrohn’s diseaseInfliximabMucosal healingTrefoil factors

Identifiers

PMID28104989
PMCPMC5221277
OpenAlexW2568219723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.