ArticleInternational journal of obesity (2005)2017
Overexpression of bone morphogenetic protein-3b (BMP-3b) in adipose tissues protects against high-fat diet-induced obesity.
Article in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- The Impact of Obesity on Thyroid Autoimmunity and Dysfunction: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2019Pooled it
- Growth differentiation factor 10 inhibits fat infiltration in tongue muscles of mice with high-fat diet.Skeletal muscle · 2025Article
- Autocrine GDF10 Inhibits Hepatic Stellate Cell Activation via BMPR2/ALK3 Receptor to Prevent Liver Fibrosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Impacts of dietary fat on multi tissue gene expression in the desert-adapted cactus mouse.The Journal of experimental biology · 2024Article
- MRI quantitative assessment of the effects of low-carbohydrate therapy on Hashimoto's thyroiditis.Endocrine connections · 2024Article
- Reduced plasma GDF10 levels are positively associated with cholesterol impairment and childhood obesity.Scientific reports · 2024Article
- BMP8B Activates Both SMAD2/3 and NF-κB Signals to Inhibit the Differentiation of 3T3-L1 Preadipocytes into Mature Adipocytes.Nutrients · 2023Article
- Bmp8a deletion leads to obesity through regulation of lipid metabolism and adipocyte differentiation.Communications biology · 2023Article
- GDF10 is related to obesity as an adipokine derived from subcutaneous adipose tissue.Frontiers in endocrinology · 2023Article
- Transgenic Expression ofInternational journal of molecular sciences · 2021Article
- Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia.The Journal of clinical investigation · 2021Article
- Deficiency of bone morphogenetic protein-3b induces metabolic syndrome and increases adipogenesis.American journal of physiology. Endocrinology and metabolism · 2020Article
- Comparative and population genomics approaches reveal the basis of adaptation to deserts in a small rodent.Molecular ecology · 2020Article
- Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication.Journal of lipid research · 2019Review
- GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury.Molecular metabolism · 2019Article
- Beyond the bone: Bone morphogenetic protein signaling in adipose tissue.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2019Review
- Bone Morphogenetic Protein (BMP)-3b Gene Depletion Causes High Mortality in a Mouse Model of Neonatal Hypoxic-Ischemic Encephalopathy.Frontiers in neurology · 2018Article
- Sex Differences in the Associations of Obesity With Hypothyroidism and Thyroid Autoimmunity Among Chinese Adults.Frontiers in physiology · 2018Article
- Adipose tissue plasticity and the pleiotropic roles of BMP signaling.The Journal of biological chemistryReview
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBone morphogenetic protein-3b (BMP-3b) is a member of the transforming growth factor-β superfamily and has several activities that differ from those of other BMPs. We previously found that BMP-3b is highly expressed in adipocytes, its level is increased during obesity, and it inhibits adipogenesis by suppressing peroxisome proliferator-activated receptor γ (PPARγ) in vitro. However, the function of BMP-3b in adipose tissues in vivo remains unknown.
methodsTo determine the role of BMP-3b overexpression in adipose tissues in vivo, we generated transgenic mice (BMP-3b Tg) by using a conditional overexpression approach in fatty acid-binding protein 4-expressing adipocytes. We examined BMP-3b Tg mice fed a high-fat diet to elucidate the effects of BMP-3b on obesity. Adipocyte function was evaluated as expression of adipogenic and lipogenic markers in adipose tissue. We also performed glucose and insulin tolerance tests (GTT and ITT, respectively), and biochemical analysis of serum and measured energy expenditure by indirect calorimetry.
resultsBMP-3b Tg mice fed a high-fat diet showed decreases in weight gain, fat-pad mass and adipocyte area, compared with wild-type mice. The adipose tissues of BMP-3b Tg mice showed downregulated expression of PPARγ and its target gene encoding fatty acid translocase/CD36. In addition, BMP-3b Tg mice had decreased blood glucose levels on GTT and ITT, and their serum leptin levels were decreased and adiponectin concentrations were increased. These changes in BMP-3b Tg mice were accompanied by increased energy expenditure, indicated as increased locomotor activity and oxygen consumption.
conclusionsThese results provide in vivo evidence that BMP-3b regulates adipocyte function to cause an anti-obesity effect.
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