SynthesisStroke2017
Trends in Recruitment Rates for Acute Stroke Trials, 1990-2014.
Synthesis in Stroke, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- A systematic review of the efficiency of recruitment to stroke rehabilitation randomised controlled trials.Trials · 2020Pooled it
- Shifts in Clinical Practice-Changing Acute Ischemic Stroke Research Over the Past Decade.Stroke (Hoboken, N.J.) · 2026Article
- Measuring the added benefits of decentralized trial elements (SHASTA): impact on enrollment, demographics, and data completeness through a single sponsor.Scientific reports · 2026Article
- Shifts in Clinical Practice-Changing Acute Ischemic Stroke Research Over the Last Decade.medRxiv : the preprint server for health sciences · 2026Article
- Patient engagement and shared decision-making in trial recruitment intervention studies: a systematic review.Research involvement and engagement · 2025Review
- Neuroengineering approaches assessing structural and functional changes of motor descending pathways in stroke.Progress in biomedical engineering (Bristol, England) · 2025Review
- Describing the content of trial recruitment interventions using the TIDieR reporting checklist: a systematic methodology review.BMC medical research methodology · 2024Article
- Article
- Using Epidemiological Data to Inform Clinical Trial Feasibility Assessments: A Case Study.Stroke · 2023Article
- Why Are Stroke Rehabilitation Trial Recruitment Rates in Single Digits?Frontiers in neurology · 2021Article
- Video Narratives Intervention Among Stroke Survivors: Feasibility and Acceptability Study of a Randomized Controlled Trial.JMIR aging · 2020Article
- Seven-Year Experience From the National Institute of Neurological Disorders and Stroke-Supported Network for Excellence in Neuroscience Clinical Trials.JAMA neurology · 2020Article
- Does Measurement of Corticospinal Tract Involvement Add Value to Clinical Behavioral Biomarkers in Predicting Motor Recovery after Stroke?Neural plasticity · 2020Article
- Recruitment challenges in stroke neurorecovery clinical trials.Contemporary clinical trials communications · 2019Article
- Eligibility Screening for an Early Upper Limb Stroke Rehabilitation Study.Frontiers in neurology · 2019Article
- A Three-Site Clinical Feasibility Study of a Flexible Functional Electrical Stimulation System to Support Functional Task Practice for Upper Limb Recovery in People With Stroke.Frontiers in neurology · 2019Article
- Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
3 authors.
Funding
Abstract
background and purposeSlow recruitment in acute stroke trials hampers the evaluation of new therapies and delays the adoption of effective therapies into clinical practice. This systematic review evaluates whether recruitment efficiency and rates have increased in acute stroke trials from 1990 to 2014.
methodsAcute stroke trials from 2010 to 2014 were identified by a search of PubMed, Medline, the Cochrane Database of Research in Stroke, and the Stroke Trials Registry. These trials were compared to a previously published data set of trials conducted from 1990 to 2004.
resultsThe median recruitment efficiency of trials from 1990 to 2004 was 0.41 participants/site/month compared with 0.26 participants/site/month from 2010 to 2014 (
conclusionsFor acute stroke trials, neither recruitment efficiency nor recruitment rates have increased over the past 25 years and, if anything, have declined.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.