Evidence map›Paper›PMID 28104704›Full record

ReviewMolecular & cellular proteomics : MCP2017

The Promise of Proteomics in the Study of Oncogenic Viruses.

Alison A McBride

Open access · hybridAbstract readReview
In one paragraph

Review in Molecular & cellular proteomics : MCP, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Oncolytic viruses: advanced strategies in cancer therapy.Signal transduction and targeted therapy · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. InvestigatingMolecular & cellular proteomics : MCP · 2019
    Article
  11. Dual Analysis of Virus-Host Interactions: The Case ofEvolutionary bioinformatics online · 2019
    Review
  12. Article
  13. Review
  14. The Host-Pathogen Ecosystem Viewed Through the Prism of Proteomics.Molecular & cellular proteomics : MCP · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Alison A McBrideFrom the ‡Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, 33 North Drive, MSC3209, National Institutes of Health, Bethesda, Maryland 20892 amcbride@nih.gov.ORCID 0000-0001-5607-5157
National Institute of Allergy and Infectious Diseases · US

Funding

Replication mechanisms of human papillomaviruses (HPV)ZIAAI000713 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MCBRIDE, ALISON · 2009 to 2025
$12.4M
Papillomavirus Bioinformatics ResourceZIAAI001071 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MCBRIDE, ALISON · 2009 to 2025
$1.8M
Characterization: Papillomavirus Regulatory ProteinsZ01AI000713 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI MCBRIDE, ALISON · 1994 to 2008
$1.4M
Papillomavirus Bioinformatics ResourceZ01AI001071 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MCBRIDE, ALISON · 2008 to 2008
$48k
Intramural NIH HHS Z01 AI000713Intramural NIH HHS Z01 AI001071Intramural NIH HHS ZIA AI000713Intramural NIH HHS ZIA AI001071
6 · The paper itself

Abstract

Oncogenic viruses are responsible for about 15% human cancers. This article explores the promise and challenges of viral proteomics in the study of the oncogenic human DNA viruses, HPV, McPyV, EBV and KSHV. These viruses have coevolved with their hosts and cause persistent infections. Each virus encodes oncoproteins that manipulate key cellular pathways to promote viral replication and evade the host immune response. Viral proteomics can identify cellular pathways perturbed by viral infection, identify cellular proteins that are crucial for viral persistence and oncogenesis, and identify important diagnostic and therapeutic targets.

Indexed as

DNA Virus InfectionsHost-Pathogen InteractionsHumansNeoplasmsOncogene ProteinsOncogenic VirusesProteomicsViral ProteinsVirus ReplicationOncogene ProteinsViral Proteins

Identifiers

PMID28104704
PMCPMC5393395
OpenAlexW2573883301

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.