ArticleAJNR. American journal of neuroradiology2017
Cortical Thickness of Native Tibetans in the Qinghai-Tibetan Plateau.
Article in AJNR. American journal of neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of long-term exposure to high altitude on brain structure in healthy people: an MRI-based systematic review and meta-analysis.Frontiers in psychiatry · 2023Pooled it
- Evaluation of cerebral blood flow and glymphatic function in acute mountain sickness by MRI ASL and DTI ALPS.Scientific reports · 2026Article
- Exploratory analysis of high-altitude effects on brain morphology and myelination in native Tibetan infants.Translational pediatrics · 2026Article
- Incremental ascent to 4300 m does not alter standing balance in lowlanders or Tibetan highlanders.European journal of applied physiology · 2025Article
- Longitudinal assessment of retinal and visual pathway electrophysiology and structure after high altitude exposure.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Intracranial Structural Malformations in Children in Tibet: CT and MRI Findings in a Single Tertiary Center.Current medical imaging · 2025Article
- Investigating Sea-Level Brain Predictors for Acute Mountain Sickness: A Multimodal MRI Study before and after High-Altitude Exposure.AJNR. American journal of neuroradiology · 2024Article
- Association of sugar-sweetened beverage consumption and sleep quality with anxiety symptoms: a cross-sectional study of Tibetan college students at high altitude.Frontiers in psychology · 2024Article
- Consistent differences in brain structure and functional connectivity in high-altitude native Tibetans and immigrants.Brain imaging and behavior · 2023Article
- Resting-State Neuronal Activity and Functional Connectivity Changes in the Visual Cortex after High Altitude Exposure: A Longitudinal Study.Brain sciences · 2022Article
- The human brain in a high altitude natural environment: A review.Frontiers in human neuroscience · 2022Review
- Electrophysiological mechanisms underlying hypoxia-induced deficits in visual spatial and non-spatial discrimination.Physiological reports · 2021Article
- Study of Brain Structure and Function in Chronic Mountain Sickness Based on fMRI.Frontiers in neurology · 2021Article
- Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study.Frontiers of medicine · 2020Article
- Neural network correlates of high-altitude adaptive genetic variants in Tibetans: A pilot, exploratory study.Human brain mapping · 2020Article
- Abnormal brain activity in rats with sustained hypobaric hypoxia exposure: a resting-state functional magnetic resonance imaging study.Chinese medical journal · 2019Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeHigh-altitude environmental factors and genetic variants together could have exerted their effects on the human brain. The present study was designed to investigate the cerebral morphology in high-altitude native Tibetans. MATERIALS AND
methodsT1-weighted brain images were obtained from 77 Tibetan adolescents on the Qinghai-Tibetan Plateau (altitude, 2300-5300 m) and 80 matched Han controls living at sea level. Cortical thickness, curvature, and sulcus were analyzed by using FreeSurfer.
resultsCortical thickness was significantly decreased in the left posterior cingulate cortex, lingual gyrus, superior parietal cortex, precuneus, and rostral middle frontal cortex and the right medial orbitofrontal cortex, lateral occipital cortex, precuneus, and paracentral lobule. Curvature was significantly decreased in the left superior parietal cortex and right superior marginal gyrus; the depth of the sulcus was significantly increased in the left inferior temporal gyrus and significantly decreased in the right superior marginal gyrus, superior temporal gyrus, and insular cortex. Moreover, cortical thickness was negatively correlated with altitude in the left superior and middle temporal gyri, rostral middle frontal cortex, insular cortex, posterior cingulate cortex, precuneus, lingual gyrus, and the right superior temporal gyrus. Curvature was positively correlated with altitude in the left rostral middle frontal cortex, insular cortex, and middle temporal gyrus. The depth of the sulcus was negatively correlated with altitude in the left lingual gyrus and right medial orbitofrontal cortex.
conclusionsDifferences in cortical morphometry in native Tibetans may reflect adaptations related to high altitude.
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