Evidence map›Paper›PMID 28104455›Full record

ArticleFree radical biology & medicine2017

A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance.

Jade Bailey, Andrew Shaw, Roman Fischer, Brent J Ryan, Benedikt M Kessler, James McCullagh, Richard Wade-Martins, Keith M Channon, Mark J Crabtree

Open access · hybridAbstract read
In one paragraph

Article in Free radical biology & medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 54 citations in OpenAlex.

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  13. Journal of clinical biochemistry and nutrition · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jade BaileyBHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom.
Andrew ShawBHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom.
Roman FischerTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, United Kingdom.
Brent J RyanOxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, United Kingdom.
Benedikt M KesslerTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, United Kingdom.
James McCullaghDepartment of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QR, United Kingdom.
Richard Wade-MartinsOxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, United Kingdom.
Keith M ChannonBHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom. Electronic address: keith.channon@cardiov.ox.ac.uk.
Mark J CrabtreeBHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom.
University of Oxford · GBJohn Radcliffe Hospital · GB

Funding

British Heart Foundation FS/14/56/31049British Heart Foundation RE/13/1/30181British Heart Foundation RG/07/003/23133British Heart Foundation RG/12/5/29576British Heart Foundation RG/17/10/32859Department of HealthParkinson's UK G-0801Parkinson's UK J-0901Wellcome Trust 090532/Z/09/Z
6 · The paper itself

Abstract

The redox co-factor tetrahydrobiopterin (BH

Indexed as

AnimalsBiopterinsCardiovascular DiseasesEndotheliumEnergy MetabolismGTP CyclohydrolaseHumansMiceMitochondriaNitric OxideNitric Oxide Synthase Type IIIOxidation-ReductionReactive Oxygen SpeciesBiopterinsGTP CyclohydrolaseNitric OxideNitric Oxide Synthase Type IIIReactive Oxygen SpeciessapropterinMitochondriaNitric oxide synthaseRedox stateSuperoxideTetrahydrobiopterin

Identifiers

PMID28104455
PMCPMC5338462
OpenAlexW2577859427

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.