ArticleDevelopmental biology2017
Intestinal stem cell ablation reveals differential requirements for survival in response to chemical challenge.
Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Intrinsic regulation of intestinal stem cell fate and homeostasis by Tet.bioRxiv : the preprint server for biology · 2026Article
- Wdr4 regulates ribosome biogenesis and intestinal homeostasis via let-7.EMBO reports · 2026Article
- The transmembrane protein Syndecan is required for stem cell survival and maintenance of their nuclear properties.PLoS genetics · 2025Article
- Article
- Dual role for Headcase in hemocyte progenitor fate determination in Drosophila melanogaster.PLoS genetics · 2024Article
- Taurine represses age-associated gut hyperplasia in Drosophila via counteracting endoplasmic reticulum stress.Aging cell · 2021Article
- Systemic and local effect of the Drosophila headcase gene and its role in stress protection of Adult Progenitor Cells.PLoS genetics · 2021Article
- Functional Transcription Factor Target Networks Illuminate Control of Epithelial Remodelling.Cancers · 2020Article
- The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila.Stem cell reports · 2020Article
- Article
- Intestinal renewal across the animal kingdom: comparing stem cell activity in mouse and Drosophila.American journal of physiology. Gastrointestinal and liver physiology · 2019Review
- The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling.Cell reports · 2019Article
- Article
- Review
- Loss ofeLife · 2017Article
- Pink1 and Parkin regulateThe Journal of cell biology · 2017Article
- Intestinal Stem Cell Pool Regulation in Drosophila.Stem cell reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Drosophila intestine is maintained by multipotent intestinal stem cells (ISCs). Although increased intestinal stem cell (ISC) proliferation has been correlated with a decrease in longevity, there is some discrepancy regarding whether a decrease or block in proliferation also has negative consequences. Here we identify headcase (hdc) as a novel marker of ISCs and enteroblasts (EBs) and demonstrate that Hdc function is required to prevent ISC/EB loss through apoptosis. Hdc depletion was used as a strategy to ablate ISCs and EBs in order to test the ability of flies to survive without ISC function. While flies lacking ISCs showed no major decrease in survival under unchallenged conditions, flies depleted of ISCs and EBs exhibited decreased survival rates in response to damage to mature enterocytes (EC) that line the intestinal lumen. Our findings indicate that constant renewal of the intestinal epithelium is not absolutely necessary under normal laboratory conditions, but it is important in the context of widespread chemical-induced damage when significant repair is necessary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.