Evidence map›Paper›PMID 28103947›Full record

ArticleJournal of hematology & oncology2017

Long-term immune reconstitution and T cell repertoire analysis after autologous hematopoietic stem cell transplantation in systemic sclerosis patients.

Dominique Farge, Lucas C M Arruda, Fanny Brigant, Emmanuel Clave, Corinne Douay, Zora Marjanovic, Christophe Deligny, Guitta Maki, Eliane Gluckman, Antoine Toubert and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of hematology & oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 72 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 4 countries.

Dominique FargeUnité de Médecine Interne, Maladies Autoimmunes et Pathologie Vasculaire, UF 04, Assistance Publique Hopitaux de Paris AP-HP, Hôpital Saint-Louis, Paris, France. dominique.farge-bancel@aphp.fr.
Lucas C M ArrudaINSERM UMR-1160, Institut Universitaire d'Hématologie, Paris, France.
Fanny BrigantINSERM UMR-1160, Institut Universitaire d'Hématologie, Paris, France.
Emmanuel ClaveINSERM UMR-1160, Institut Universitaire d'Hématologie, Paris, France.
Corinne DouayINSERM UMR-1160, Institut Universitaire d'Hématologie, Paris, France.
Zora MarjanovicDépartement d'Hématologie, AP-HP, Hôpital Saint-Antoine, Paris, France.
Christophe DelignyService de Médecine Interne, Hôpital Pierre Zobda Quitman, Fort-de France, Martinique, France.
Guitta MakiLaboratoire d'Immunologie-Histocompatibilité, AP-HP, Hôpital Saint Louis, Paris, France.
Eliane GluckmanEurocord-Monacord, AP-HP, Hôpital Saint-Louis, Paris, France.
Antoine ToubertINSERM UMR-1160, Institut Universitaire d'Hématologie, Paris, France.
Helene Moins-TeisserencINSERM UMR-1160, Institut Universitaire d'Hématologie, Paris, France.
Assistance Publique – Hôpitaux de Paris · FRHôpital Saint-Louis · FRCentre Hospitalier Universitaire de Martinique · MQClinics Hospital of Ribeirão Preto · BRDélégation Paris 7 · FRHôpital Saint-Antoine · FRInserm · FRSorbonne Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The determinants of clinical responses after autologous hematopoietic stem cell transplantation (aHSCT) in systemic sclerosis (SSc) are still unraveled. We analyzed long-term immune reconstitution (IR) and T cell receptor (TCR) repertoire diversity in 10 SSc patients, with at least 6 years simultaneous clinical and immunological follow-up after aHSCT. Patients were retrospectively classified as long-term responders (A, n = 5) or non-responders (B, n = 5), using modified Rodnan's skin score (mRSS) and forced vital capacity (FVC%). All patients had similar severe SSc before aHSCT. Number of reinjected CD34

Indexed as

Hematopoietic Stem Cell TransplantationAdultAntigens, Differentiation, T-LymphocyteCell CountFemaleFollow-Up StudiesGraft SurvivalHumansImmunophenotypingMaleMiddle AgedScleroderma, DiffuseSeverity of Illness IndexSkinT-Lymphocyte SubsetsTransplantation, AutologousAntigens, Differentiation, T-LymphocyteHematopoietic stem cell transplantationImmune reconstitutionSystemic sclerosisT cell repertoire

Identifiers

PMID28103947
PMCPMC5244700
OpenAlexW2574894411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.