ArticleLipids in health and disease2017
The triglyceride and glucose index (TyG) is an effective biomarker to identify nonalcoholic fatty liver disease.
Article in Lipids in health and disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers, 4 of them syntheses that pooled it.
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Who cites it
176 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Triglyceride glucose waist circumference and non alcoholic fatty liver disease: a systematic review and meta analysis.BMC gastroenterology · 2025Pooled it
- The triglyceride-glucose index as a biomarker of diabetic retinopathy: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Pooled it
- The triglyceride and glucose index and risk of nonalcoholic fatty liver disease: A dose-response meta-analysis.Frontiers in endocrinology · 2022Pooled it
- The effect of chitosan supplementation on liver function, hepatic steatosis predictors, and metabolic indicators in adults with non-alcoholic fatty liver disease: a randomized, double-blinded, placebo-controlled, clinical trial.Journal of health, population, and nutrition · 2025Trial
- Risk factors and prediction model for nonalcoholic fatty liver disease in northwest China.Scientific reports · 2022Trial
- Pentraxin 3 and the TyG Index as Two Novel Markers to Diagnose NAFLD in Children.Disease markers · 2021Trial
- Fruit Fiber Consumption Specifically Improves Liver Health Status in Obese Subjects under Energy Restriction.Nutrients · 2017Trial
- The triglyceride-glucose index as a predictor of cardiovascular disease: an umbrella review of meta-analyses.Annals of medicine and surgery (2012) · 2026Article
- Associations of General and Central Obesity with Cardiovascular Risk by Menopausal and MASLD Status.Biomedicines · 2026Article
- Association between the TyG/HDL-C ratio and non-alcoholic fatty liver disease: a single-centre retrospective study.BMC gastroenterology · 2026Article
- TyG-Centered Endocrine-Metabolic Architecture in Patients with Thyroid Dysfunction: A Systems Phenotyping Study.Metabolites · 2026Article
- Hepatic Steatosis Severity Prediction in Nonobese Individuals: Machine Learning Model Development and Validation.Journal of medical Internet research · 2026Article
- Predictive significance of triglyceride-glucose index in forecasting adverse cardiovascular events among Type 2 diabetes mellitus patients with co-existing metabolic dysfunction-associated steatotic liver disease (MASLD): evidence from two cohort studies.Cardiovascular diabetology · 2026Article
- Comparative Diagnostic Performance of Metabolic Scoring Indices for Ultrasonographic Hepatic Steatosis: Development and Validation of a Novel Composite Score in 1204 Consecutive Patients.Journal of clinical medicine · 2026Article
- Triglyceride glucose-body mass index as a practical screening tool for metabolic dysfunction-associated steatotic liver disease in older adults: A community-based cohort study.Asia Pacific journal of clinical nutrition · 2026Article
- Article
- The association of the combined triglyceride-glucose and frailty index with chronic liver disease: evidence from the CHARLS study.BMC gastroenterology · 2026Article
- Association of the Triglyceride-Glucose Index With Gallstone Disease: A Systematic Review and Meta-Analysis of Observational Studies.JGH open : an open access journal of gastroenterology and hepatology · 2026Review
- TyG index combined with BMI predicts metabolism dysfunction-associated fatty liver disease in patients with type 2 diabetes.Open medicine (Warsaw, Poland) · 2026Article
116 more citing papers are in PubMed but not listed here.
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe triglyceride and glucose index (TyG) has been proposed as a marker of insulin resistance. We aimed to investigate the ability of TyG, through comparing with the predictive value of alanine aminotransferase (ALT), to identify individuals at risk for nonalcoholic fatty liver disease (NAFLD).
methodsA cross-sectional study was conducted in a Chinese health examination cohort of 10 761 people aged above 20 years. NAFLD was diagnosed by ultrasonography.
resultsCompared with the participants in the lowest quartile of TyG, the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were 1.8 (1.5-2.1), 3.0 (2.5-3.5), and 6.3 (5.3-7.5) for those in the second, the third, and the fourth quartile of TyG, whereas the corresponding ORs (95% CI) for NAFLD were 1.5 (1.3-1.7), 1.9 (1.6-2.2), and 3.1 (2.6-3.7) for the upper three quartiles of ALT. These results suggested that TyG was superior to ALT in association with NAFLD risk. According to the ROC analysis, the optimal cut-off point of TyG for NAFLD was 8.5 and the area under the ROC curve (AUC) was 0.782 (95% CI 0.773-0.790), with 72.2 and 70.5% sensitivity and specificity, respectively. The AUC of TyG was larger than that of ALT (0.715 (95% CI 0.705-0.725), P for difference <0.0001), whereas the largest AUC was obtained when adding TyG to ALT (0.804 (95% CI 0.795-0.812), P for difference <0.0001).
conclusionsTyG is effective to identify individuals at risk for NAFLD. A TyG threshold of 8.5 was highly sensitive for detecting NAFLD subjects and may be suitable as a diagnostic criterion for NAFLD in Chinese adults.
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