ArticleCancer imaging : the official publication of the International Cancer Imaging Society2017
Assessment and diagnostic accuracy of lymph node status to predict stage III colon cancer using computed tomography.
Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- CT diagnostic performance for preoperative staging of colon cancer: a systematic review and meta-analysis.European radiology · 2026Pooled it
- CT staging performance in an international trial of neoadjuvant chemotherapy for locally advanced colon cancer.The British journal of radiology · 2025Trial
- Preoperative assessment of lymph node metastasis in Colon Cancer patients using machine learning: a pilot study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2020Trial
- Novel scoring system for the preoperative computed tomographic diagnosis of lymph node metastasis in colorectal cancer patients.Surgery today · 2026Article
- Current Status and Challenges of Imaging-Based Diagnosis of Lymph Node Metastasis in Colon Cancer: The Lymph Node Committee of the Japanese Society for Cancer of the Colon and Rectum.Annals of gastroenterological surgery · 2026Review
- CT-based Node-RADS classification in the assessment of rectal cancer: diagnostic performance and postoperative prognostic stratification.BMC cancer · 2026Article
- Computed tomography staging of colon cancer: improved patient selection for neoadjuvant therapy with combined radiologic tumor and nodal staging.BMC cancer · 2026Article
- Preoperative risk stratification of colorectal high-grade intraepithelial neoplasia based on endoscopic biopsy: superior performance ofQuantitative imaging in medicine and surgery · 2025Article
- Analysis of the clinical value of gemstone spectral computed tomography imaging in the preoperative assessment of colorectal cancer.World journal of gastrointestinal surgery · 2025Article
- Prognostic value of routine blood biomarkers in 3-year survival of resectable colorectal cancer patients: a prognostic nomogram for clinical practice.International journal of colorectal disease · 2025Observational
- Constructing a nomogram to predict overall survival of colon cancer based on computed tomography characteristics and clinicopathological factors.World journal of gastrointestinal oncology · 2024Article
- Performances of preoperative CT scan to predict the pTN stage for MSI/dMMR localized colon cancers.ESMO open · 2024Article
- Performance of CT in the locoregional staging of colon cancer: detailed radiology-pathology correlation with special emphasis on tumor deposits, extramural venous invasion and T staging.Abdominal radiology (New York) · 2024Article
- Prognostic impact of extramural venous invasion detected by contrast-enhanced CT colonography in colon cancer.BJS open · 2024Article
- Deficient mismatch repair/microsatellite unstable colorectal cancer: therapeutic advances and questions.Therapeutic advances in medical oncology · 2024Review
- Small arteriole sign: an imaging feature for staging T4a colon cancer.European radiology · 2024Article
- Diagnostic Performance of Rectal CT for Staging Rectal Cancer: Comparison with Rectal MRI and Histopathology.Journal of the Korean Society of Radiology · 2023Article
- CT morphological features for predicting the risk of lymph node metastasis in T1 colorectal cancer.European radiology · 2023Article
- Radiologic T staging of colon cancer: renewed interest for clinical practice.Abdominal radiology (New York) · 2023Review
- Added value of spectral parameters in diagnosing metastatic lymph nodes of pT1-2 rectal cancer.Abdominal radiology (New York) · 2023Article
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Abstract
backgroundTo study different imaging criteria for prediction of lymph node metastases (Stage III disease) in colon cancer using CT.
methodsIn a retrospective setting, 483 consecutive patients with histology proven colon cancer underwent elective primary resection during 2008-2011, a cohort of 119 patients were included. Contrast enhanced CT examinations, in portal-venous phase, were reviewed with assessment of the number of lymph nodes, their anatomical distribution, size, size ratio, internal heterogeneity, presence of irregular outer border and attenuation values. Sensitivity, specificity, PPV and NPV for each studied criteria for prediction of stage III disease was calculated.
resultsAccording to histopathology 80 patients were stage I-II and 39 were stage III. Of the studied CT-criteria for lymph node metastases per patient, internal heterogeneity in at least one lymph node resulted in the best performance with sensitivity, specificity, PPV and NPV of 79, 84, 70 and 89%, Odds ratio (OR) 20. Presence of irregular outer border resulted in a sensitivity, specificity, PPV and NPV of 59, 81, 61 and 82%, OR 6.2. If both internal heterogeneity and/or irregular outer border was used as a criterion this resulted in a sensitivity, specificity, PPV and NPV of 85, 75, 62 and 91%, OR 16.5. None of the size criteria used were predictive for stage III disease.
conclusionsWhen performing preoperative CT in patients with colon cancer, the imaging criteria that allow best prediction of stage III disease on CT are either presence of at least one lymph node with internal heterogeneity or internal heterogeneity and/or irregular outer border. These criteria have to be validated in a prospective study.
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