ArticleBMC nephrology2017
Genetic risk score and risk of stage 3 chronic kidney disease.
Article in BMC nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis.Nature communications · 2019Pooled it
- An early prediction model for chronic kidney disease.Scientific reports · 2022Trial
- Genetic risk score for risk prediction of diabetic nephropathy in Han Chinese type 2 diabetes patients.Scientific reports · 2019Trial
- Large-scale evaluation of proteomic and polygenic risk scores reveals complementary contributions to incident disease prediction.medRxiv : the preprint server for health sciences · 2025Article
- Approaches to predict future type 2 diabetes mellitus and chronic kidney disease: A scoping review.PloS one · 2025Article
- Chronic Kidney Disease of Unknown Etiology: A Global Health Threat in Rural Agricultural Communities-Prevalence, Suspected Causes, Mechanisms, and Prevention Strategies.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Review
- A methylation risk score for chronic kidney disease: a HyperGEN study.Scientific reports · 2024Article
- Epigenetic Age Mediates the Association of Life's Essential 8 With Cardiovascular Disease and Mortality.Journal of the American Heart Association · 2024Article
- Genome-wide association studies reconstructing chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Review
- A BAYESIAN DECISION FRAMEWORK FOR OPTIMIZING SEQUENTIAL COMBINATION ANTIRETROVIRAL THERAPY IN PEOPLE WITH HIV.The annals of applied statistics · 2023Article
- Longitudinal association between overweight years, polygenic risk and NAFLD, significant fibrosis and cirrhosis.Alimentary pharmacology & therapeutics · 2023Article
- Risk prediction of nephropathy by integrating clinical and genetic information among adult patients with type 2 diabetes.Acta diabetologica · 2023Review
- Bitter- and Umami-Related Genes are Differentially Associated with Food Group Intakes: the Framingham Heart Study.The Journal of nutrition · 2023Article
- Polygenic association of glomerular filtration rate decline in world trade center responders.BMC nephrology · 2022Article
- Associations of Genetic Factors, Educational Attainment, and Their Interaction With Kidney Function Outcomes.American journal of epidemiology · 2021Article
- Genetic risk score raises the risk of incidence of chronic kidney disease in Korean general population-based cohort.Clinical and experimental nephrology · 2019Article
- Genetic Predisposition for Renal Dysfunction and Incidence of CKD in the Malmö Diet and Cancer Study.Kidney international reports · 2019Article
- Increased Diet Quality is Associated with Long-Term Reduction of Abdominal and Pericardial Fat.Obesity (Silver Spring, Md.) · 2019Article
- Association of Candidate Gene Polymorphisms With Chronic Kidney Disease: Results of a Case-Control Analysis in the Nefrona Cohort.Frontiers in genetics · 2019Article
- Improved Diet Quality Associates With Reduction in Liver Fat, Particularly in Individuals With High Genetic Risk Scores for Nonalcoholic Fatty Liver Disease.Gastroenterology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWe developed a genetic risk score (GRS) and examined whether the GRS may predict incident stage 3 chronic kidney disease (CKD) independent of common clinical risk factors.
methodThe present study included 2,698 individuals who attended the 15th (1977 to 1979) and the 24th exams (1995 to 1998) in the Framingham Original cohort or the 6th (1995 to 1998) and the 8th exams (2005 to 2008) in the Framingham Offspring cohort. A weighted GRS was constructed combining 53 single nucleotide polymorphisms (SNPs) associated with lower creatinine-based estimated glomerular filtration rate (eGFR). Stage 3 CKD was defined as eGFR <60 mL/min/1.73 m
resultsA total of 292 incident cases and 2,406 non-cases were identified over, on average, 11 years of follow-up. After adjustment for sex, age, cohort, baseline eGFR, hypertension, diabetes, and dipstick proteinuria, the odds ratio of incident stage 3 CKD was 1.37 (95%CI: 1.02-1.83) per 10 alleles of the GRS (P = 0.04). There was no statistically significant difference between the C-statistic without and with inclusion of the GRS (0.783 and 0.785, respectively; P = 0.39).
conclusionsA GRS developed based on 53 SNPs associated with reduced eGFR was prospectively associated with incident stage 3 CKD. However, this score did not substantially improve discrimination of stage 3 CKD beyond the common clinical risk factors.
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