Evidence map›Paper›PMID 28103450›Full record

ReviewExpert review of molecular diagnostics2017

Paper-based analytical devices for clinical diagnosis: recent advances in the fabrication techniques and sensing mechanisms.

Mazhar Sher, Rachel Zhuang, Utkan Demirci, Waseem Asghar

Abstract readReview
In one paragraph

Review in Expert review of molecular diagnostics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Challenges in Direct Detection of Flaviviruses: A Review.Pathogens (Basel, Switzerland) · 2023
    Review
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  16. Innovative Quantification of Critical Quality Attributes.Advances in experimental medicine and biology · 2023
    Article
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  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mazhar Shera Computer Engineering & Electrical Engineering and Computer Science Lab , Florida Atlantic University , Boca Raton , FL , USA.
Rachel Zhuangb Asghar-Lab, Micro and Nanotechnology for Medicine , College of Engineering and Computer Science , Boca Raton , FL , USA.
Utkan Demircic The Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology , Stanford School of Medicine , Palo Alto , CA , USA.
Waseem Asghara Computer Engineering & Electrical Engineering and Computer Science Lab , Florida Atlantic University , Boca Raton , FL , USA.

Funding

Rapid Fluorescence-Based Determination of Antibiotic SusceptibilityU54EB015408 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI PARRISH, JOHN A, SCHACHTER, STEVEN · 2012 to 2022
$49.2M
Point-of-Care Rapid Blood Testing Using Microfluidic DevicesR01AI081534 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMIRCI, UTKAN · 2009 to 2013
$2.1M
Platform technology for detection of cancer-associated viruses in HIV patientsR01DE024971 · NIDCR · STANFORD UNIVERSITY · PI DEMIRCI, UTKAN, KAYE, KENNETH M · 2015 to 2019
$2.1M
Novel disposable microchips for HIV-1 viral loadR01AI093282 · NIAID · STANFORD UNIVERSITY · PI DEMIRCI, UTKAN · 2012 to 2015
$1.7M
Rapid Disease Diagnostics using Photonic Crystal Enhanced Antigen BiomarkerR01GM108584 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ANDERSON, KAREN SUE, CUNNINGHAM, BRIAN T. · 2014 to 2017
$1.6M
Portable Nanostructured Photonic Crystal Device for HIV-1 Viral LoadR01AI120683 · NIAID · STANFORD UNIVERSITY · PI CUNNINGHAM, BRIAN T., DEMIRCI, UTKAN · 2016 to 2019
$1.5M
Development of disposable and refrigeration-free microchip technology for CD4+ T cell counting at point-of-care settingsR15AI127214 · NIAID · FLORIDA ATLANTIC UNIVERSITY · PI ASGHAR, WASEEM · 2016 to 2016
$460k
NIAID NIH HHS R01 AI081534NIAID NIH HHS R01 AI093282NIAID NIH HHS R01 AI120683NIAID NIH HHS R15 AI127214NIBIB NIH HHS U54 EB015408NIDCR NIH HHS R01 DE024971NIGMS NIH HHS R01 GM108584
6 · The paper itself

Abstract

introductionThere is a significant interest in developing inexpensive portable biosensing platforms for various applications including disease diagnostics, environmental monitoring, food safety, and water testing at the point-of-care (POC) settings. Current diagnostic assays available in the developed world require sophisticated laboratory infrastructure and expensive reagents. Hence, they are not suitable for resource-constrained settings with limited financial resources, basic health infrastructure, and few trained technicians. Cellulose and flexible transparency paper-based analytical devices have demonstrated enormous potential for developing robust, inexpensive and portable devices for disease diagnostics. These devices offer promising solutions to disease management in resource-constrained settings where the vast majority of the population cannot afford expensive and highly sophisticated treatment options. Areas covered: In this review, the authors describe currently developed cellulose and flexible transparency paper-based microfluidic devices, device fabrication techniques, and sensing technologies that are integrated with these devices. The authors also discuss the limitations and challenges associated with these devices and their potential in clinical settings. Expert commentary: In recent years, cellulose and flexible transparency paper-based microfluidic devices have demonstrated the potential to become future healthcare options despite a few limitations such as low sensitivity and reproducibility.

Indexed as

Point-of-Care SystemsChemistry Techniques, AnalyticalHumansPaperbiosensorscellulose paper-based analytical devicesdevice fabricationflexible transparency paper-based analytical devicesmicrofluidicsPoint-of-care diagnostics

Identifiers

PMID28103450
PMCPMC5529145

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.