Evidence map›Paper›PMID 28103433›Full record

Trial reportThe Korean journal of internal medicine2018

Baseline extent of damage predicts spinal radiographic progression in Korean patients with ankylosing spondylitis treated with golimumab.

Jeong Seok Lee, Yeong Wook Song, Tae Hwan Kim, Won Tae Chung, Seung Geun Lee, Sung Hwan Park, Gwan Gyu Song, Dae Young Yu, Stephen Xu, Eun Young Lee

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Korean journal of internal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jeong Seok LeeDivision of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Yeong Wook SongDivision of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Tae Hwan KimDivision of Rheumatology, Department of Internal Medicine, Hanyang University Seoul Hospital, Seoul, Korea.
Won Tae ChungDivision of Rheumatology, Department of Internal Medicine, Dong-A University Hospital, Busan, Korea.
Seung Geun LeeDivision of Rheumatology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Sung Hwan ParkDivision of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
Gwan Gyu SongDivision of Rheumatology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.
Dae Young YuJanssen Korea, Medical Affairs, Seoul, Korea.
Stephen XuDepartment of Biostatistics, Janssen Research & Development, LLC, Spring House, PA, USA.
Eun Young LeeDivision of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsFor patients with ankylosing spondylitis (AS), golimumab has consistent efficacy in controlling disease activity over 5 years but its benefit in preventing radiographic progression was less clear at 4 years. To predict radiographic progression, we analyzed the baseline characteristics of AS patients in a Korean population.

methodsSixty-eight Korean patients with AS participated in the phase 3, multicenter, randomized, placebo-controlled, double-blind trial (GO-RAISE) which has previously been described. Baseline modified stoke AS spine score (mSASSS) and change in mSASSS from baseline (ΔmSASSS) until week 208 were analyzed in the Korean patients enrolled in the GO-RAISE study.

resultsAlthough Korean patients had lower baseline mSASSS compared to non-Korean patients and received active management, radiographic progression was not prevented. Korean patients who did not undergo radiographic progression of spinal lesions of AS were younger and had shorter symptomatic duration, lower Bath AS functional and metrology indices, better chest expansion, and lower baseline mSASSS. The baseline mSASSS and ΔmSASSS were positively correlated in Korean AS patients (

conclusionsIn Korean AS patients, radiographic progression of the spine after 4 years was predicted effectively by the initial severity of the spinal lesion(s) in patients treated with golimumab.

Indexed as

Antibodies, MonoclonalSpondylitis, AnkylosingAdultDisease ProgressionDouble-Blind MethodFemaleHumansMaleRadiographyRepublic of KoreaSeverity of Illness IndexSpineYoung AdultAntibodies, MonoclonalgolimumabDisease progressionGolimumabSpondylitis, ankylosing

Identifiers

PMID28103433
PMCPMC5943646

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