ArticleChembiochem : a European journal of chemical biology2017
A Peroxygenase from Chaetomium globosum Catalyzes the Selective Oxygenation of Testosterone.
Article in Chembiochem : a European journal of chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 80 citations in OpenAlex.
- Promiscuous fungal peroxygenase fromiScience · 2026Article
- Engineering peroxygenases for pharmaceutical applications: recent advances and future perspectives.Chemical science · 2026Review
- N-Glycosylation Influences the Heterologous Expression of an Unspecific Peroxygenase From Marasmius rotula in Saccharomyces cerevisiae.Microbial biotechnology · 2026Article
- Computationally Designed Peroxygenases That Exhibit Diverse and Selective Terpene Oxyfunctionalization.ACS catalysis · 2025Article
- Identification of Key Active-Site Positions Controlling the Chemoselectivity of Aspergillus Brasiliensis Unspecific Peroxygenase.Chembiochem : a European journal of chemical biology · 2025Article
- Rapid screening system to identify unspecific peroxygenase activity.Clinical hemorheology and microcirculation · 2025Article
- Structural Insights and Reaction Profile of a New Unspecific Peroxygenase fromACS chemical biology · 2024Article
- Engineering of Unspecific Peroxygenases Using a Superfolder-Green-Fluorescent-Protein-Mediated Secretion System inJACS Au · 2024Article
- Identification, heterologous expression and characterization of a new unspecific peroxygenase from Marasmius fiardii PR-910.Bioresources and bioprocessing · 2024Article
- Novel Unspecific Peroxygenase fromMicroorganisms · 2022Article
- Oxygenating Biocatalysts for Hydroxyl Functionalisation in Drug Discovery and Development.ChemMedChem · 2022Review
- Structural Characterization of Two Short Unspecific Peroxygenases: Two Different Dimeric Arrangements.Antioxidants (Basel, Switzerland) · 2022Article
- Enzymatic Epoxidation of Long-Chain Terminal Alkenes by Fungal Peroxygenases.Antioxidants (Basel, Switzerland) · 2022Article
- Cell-Free Protein Synthesis with Fungal Lysates for the Rapid Production of Unspecific Peroxygenases.Antioxidants (Basel, Switzerland) · 2022Article
- Broadening the Biocatalytic Toolbox-Screening and Expression of New Unspecific Peroxygenases.Antioxidants (Basel, Switzerland) · 2022Article
- Peroxide-Mediated Oxygenation of Organic Compounds by Fungal Peroxygenases.Antioxidants (Basel, Switzerland) · 2022Review
- Enzyme-catalyzed allylic oxidation reactions: A mini-review.Frontiers in chemistry · 2022Review
- Regioselective and Stereoselective Epoxidation of n-3 and n-6 Fatty Acids by Fungal Peroxygenases.Antioxidants (Basel, Switzerland) · 2021Article
- Recent developments in the use of peroxygenases - Exploring their high potential in selective oxyfunctionalisations.Biotechnology advances · 2021Review
- Hemoprotein Catalyzed Oxygenations: P450s, UPOs, and Progress toward Scalable Reactions.JACS Au · 2021Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unspecific peroxygenases (UPO, EC 1.11.2.1) secreted by fungi open an efficient way to selectively oxyfunctionalize diverse organic substrates, including less-activated hydrocarbons, by transferring peroxide-borne oxygen. We investigated a cell-free approach to incorporate epoxy and hydroxyl functionalities directly into the bulky molecule testosterone by a novel unspecific peroxygenase (UPO) that is produced by the ascomycetous fungus Chaetomium globosum in a complex medium rich in carbon and nitrogen. Purification by fast protein liquid chromatography revealed two enzyme fractions with the same molecular mass (36 kDa) and with specific activity of 4.4 to 12 U mg
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.