ArticlePloS one2017
Isolation, Characterization and Evaluation of Collagen from Jellyfish Rhopilema esculentum Kishinouye for Use in Hemostatic Applications.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 186 citations in OpenAlex.
- Fish collagen for skin wound healing: a systematic review in experimental animal studies.Cell and tissue research · 2022Pooled it
- 3D printed fish scale collagen/RSC advances · 2026Article
- Collagen from Salted Jellyfish (Gels (Basel, Switzerland) · 2026Article
- Development of an HInternational journal of molecular sciences · 2026Article
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- Comparative analysis of collagen from different sources for wound and burn management.Biomaterials translational · 2026Article
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- Novel crosslinked recombinant human collagen scaffolds with excellent cytocompatibility and wound healing effect.RSC advances · 2025Article
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- Marine Jellyfish Collagen and Other Bioactive Natural Compounds from the Sea, with Significant Potential for Wound Healing and Repair Materials.Marine drugs · 2025Article
- Jellyfish Collagen in the Mediterranean Spotlight: Transforming Challenges into Opportunities.Marine drugs · 2025Review
- Recent Advancements in Marine Collagen: Exploring New Sources, Processing Approaches, and Nutritional Applications.Marine drugs · 2025Review
- Collagen-Based Wound Dressings: Innovations, Mechanisms, and Clinical Applications.Gels (Basel, Switzerland) · 2025Review
- Progress in Preparation Technology and Functional Research On Marine Bioactive Peptides.Marine biotechnology (New York, N.Y.) · 2025Review
- The Influence of Basil and Cinnamon Essential Oils on Bioactive Sponge Composites of Collagen Reinforced with Hydroxyapatite.Materials (Basel, Switzerland) · 2025Article
- Wild or Reared?Marine drugs · 2025Article
- Compounds of Marine Origin with Possible Applications as Healing Agents.Marine drugs · 2024Review
- How Significant Are Marine Invertebrate Collagens? Exploring Trends in Research and Innovation.Marine drugs · 2024Review
- The Promoting Effect of Animal Bioactive Proteins and Peptide Components on Wound Healing: A Review.International journal of molecular sciences · 2024Review
- Characterization of Collagen from Jellyfish Aurelia aurita and Investigation of Biomaterials Potentials.Applied biochemistry and biotechnology · 2024Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hemostat has been a crucial focus since human body is unable to control massive blood loss, and collagen proves to be an effective hemostat in previous studies. In this study, collagen was isolated from the mesoglea of jellyfish Rhopilema esculentum Kishinouye and its hemostatic property was studied. The yields of acid-soluble collagen (ASC) and pepsin-soluble (PSC) were 0.12% and 0.28% respectively. The SDS-PAGE patterns indicated that the collagen extracted from jellyfish mesoglea was type I collagen. The lyophilized jellyfish collagen sponges were cross-linked with EDC and interconnected networks in the sponges were revealed by scanning electron microscope (SEM). Collagen sponges exhibited higher water absorption rates than medical gauze and EDC/NHS cross-linking method could improve the stability of the collagen sponges. Compared with medical gauze groups, the blood clotting indexes (BCIs) of collagen sponges were significantly decreased (P < 0.05) and the concentration of collagen also had an influence on the hemostatic property (P < 0.05). Collagen sponges had an improved hemostatic ability compared to the gauze control in tail amputation rat models. Hemostatic mechanism studies showed that hemocytes and platelets could adhere and aggregate on the surface of collagen sponge. All properties make jellyfish collagen sponge to be a suitable candidate used as hemostatic material and for wound healing applications.
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