Evidence map›Paper›PMID 28102766›Full record

ArticleVirulence2017

Soluble P-selectin rescues mice from anthrax lethal toxin-induced mortality through PSGL-1 pathway-mediated correction of hemostasis.

Der-Shan Sun, Yao-Wen Chang, Jyh-Hwa Kau, Hsin-Hsien Huang, Pei-Hsun Ho, Yin-Jeh Tzeng, Hsin-Hou Chang

Open access · goldAbstract read
In one paragraph

Article in Virulence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Der-Shan Suna Department of Molecular Biology and Human Genetics , Tzu-Chi University , Hualien , Taiwan.
Yao-Wen Changa Department of Molecular Biology and Human Genetics , Tzu-Chi University , Hualien , Taiwan.
Jyh-Hwa Kauc Institute of Microbiology and Immunology, National Defense Medical Center , Taipei , Taiwan.
Hsin-Hsien Huangd Institute of Preventive Medicine, National Defense Medical Center , Taipei , Taiwan.
Pei-Hsun Hoa Department of Molecular Biology and Human Genetics , Tzu-Chi University , Hualien , Taiwan.
Yin-Jeh Tzenga Department of Molecular Biology and Human Genetics , Tzu-Chi University , Hualien , Taiwan.
Hsin-Hou Changa Department of Molecular Biology and Human Genetics , Tzu-Chi University , Hualien , Taiwan.
Tzu Chi University · TWNational Defense Medical Center · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As one of the virulence factors of Bacillus anthracis, lethal toxin (LT) induces various pathogenic responses including the suppression of the coagulation system. In this study, we observed that LT markedly increased the circulating soluble P-selectin (sP-sel) levels and microparticle (MP) count in wild-type but not P-selectin (P-sel, Selp

Indexed as

AnimalsAnthraxAntigens, BacterialBacillus anthracisBacterial ToxinsBlood CoagulationHemostasisHumansMembrane GlycoproteinsMiceMice, Inbred C57BLP-Selectinanthrax toxinAntigens, BacterialBacterial ToxinsMembrane GlycoproteinsP-SelectinP-selectin ligand proteinanthrax lethal toxinhemostasismicroparticleP-selectin ligand 1Soluble P-selectin

Identifiers

PMID28102766
PMCPMC5711406
OpenAlexW2576272911

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.