Evidence map›Paper›PMID 28102760›Full record

ArticleTranscription2017

PHF13: A new player involved in RNA polymerase II transcriptional regulation and co-transcriptional splicing.

Alisa Fuchs, Marcos Torroba, Sarah Kinkley

Abstract read
In one paragraph

Article in Transcription, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alisa Fuchsa Max Planck Institute for Molecular Genetics , Berlin , Germany.
Marcos Torrobaa Max Planck Institute for Molecular Genetics , Berlin , Germany.
Sarah Kinkleya Max Planck Institute for Molecular Genetics , Berlin , Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We recently identified PHF13 as an H3K4me2/3 chromatin reader and transcriptional co-regulator. We found that PHF13 interacts with RNAPIIS5P and PRC2 stabilizing their association with active and bivalent promoters. Furthermore, mass spectrometry analysis identified ∼50 spliceosomal proteins in PHF13s interactome. Here, we will discuss the potential role of PHF13 in RNAPII pausing and co-transcriptional splicing.

Indexed as

AnimalsChromatinDNA-Binding ProteinsHistone-Lysine N-MethyltransferaseHistone MethyltransferasesHistonesHumansMicePolycomb-Group ProteinsPromoter Regions, GeneticRNA Polymerase IIRNA Splice SitesTranscription FactorsTranscription, GeneticChromatinDNA-Binding ProteinsHistone-Lysine N-MethyltransferaseHistone MethyltransferasesHistonesPHF13 protein, humanPolycomb-Group ProteinsRNA Polymerase IIRNA Splice SitesTranscription Factorsbivalency and H3K4me3co-transcriptional splicingPHF13polycomb repressive complex 2 (PRC2)RNA polymerase IIRNA polymerase II pausingSPOC1transcriptional regulation

Identifiers

PMID28102760
PMCPMC5423499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.