ArticleScientific reports2017
Evaluation of region selective bilirubin-induced brain damage as a basis for a pharmacological treatment.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Effect of bilirubin on visuocortical development in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Establishment of predictive models for postoperative delirium in elderly patients after knee/hip surgery based on total bilirubin concentration: machine learning algorithms.BMC anesthesiology · 2025Article
- Transcriptomic and Proteomic Changes in the Brain Along with Increasing Phenotypic Severity in a Rat Model of Neonatal Hyperbilirubinemia.International journal of molecular sciences · 2025Article
- Exploring the inverse relationship between serum total bilirubin and systemic immune-inflammation index: insights from NHANES data (2009-2018).European journal of medical research · 2024Article
- An egg a day keeps kernicterus away.Pediatric research · 2024Article
- Molecular events in brain bilirubin toxicity revisited.Pediatric research · 2024Review
- Developing Iron Nanochelating Agents: Preliminary Investigation of Effectiveness and Safety for Central Nervous System Applications.International journal of molecular sciences · 2024Article
- Article
- Models of bilirubin neurological damage: lessons learned and new challenges.Pediatric research · 2023Review
- Bilirubin-Induced Neurological Damage: Current and Emerging iPSC-Derived Brain Organoid Models.Cells · 2022Review
- Long-Term Mental Health and Quality of Life Outcomes of Neonatal Insults in Kilifi, Kenya.Child psychiatry and human development · 2022Article
- The Effects of Bilirubin and Lumirubin on the Differentiation of Human Pluripotent Cell-Derived Neural Stem Cells.Antioxidants (Basel, Switzerland) · 2021Article
- Serum Total Bilirubin Level Is Associated With Hospital Mortality Rate in Adult Critically Ill Patients: A Retrospective Study.Frontiers in medicine · 2021Article
- The Effects of Bilirubin and Lumirubin on Metabolic and Oxidative Stress Markers.Frontiers in pharmacology · 2021Article
- Curcumin Prevents Cerebellar Hypoplasia and Restores the Behavior in Hyperbilirubinemic Gunn Rat by a Pleiotropic Effect on the Molecular Effectors of Brain Damage.International journal of molecular sciences · 2020Article
- Experimental models assessing bilirubin neurotoxicity.Pediatric research · 2020Review
- Review of bilirubin neurotoxicity I: molecular biology and neuropathology of disease.Pediatric research · 2020Review
- Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices.International journal of nanomedicine · 2020Article
- Earliest Mechanisms of Dopaminergic Neurons Sufferance in a Novel Slow Progressing Ex Vivo Model of Parkinson Disease in Rat Organotypic Cultures of Substantia Nigra.International journal of molecular sciences · 2019Article
- Histone acetylation as a new mechanism for bilirubin-induced encephalopathy in the Gunn rat.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neurologic manifestations of neonatal hyperbilirubinemia in the central nervous system (CNS) exhibit high variations in the severity and appearance of motor, auditory and cognitive symptoms, which is suggestive of a still unexplained selective topography of bilirubin-induced damage. By applying the organotypic brain culture (OBC: preserving in vitro the cellular complexity, connection and architecture of the in vivo brain) technique to study hyperbilirubinemia, we mapped the regional target of bilirubin-induced damage, demonstrated a multifactorial toxic action of bilirubin, and used this information to evaluate the efficacy of drugs applicable to newborns to protect the brain. OBCs from 8-day-old rat pups showed a 2-13 fold higher sensitivity to bilirubin damage than 2-day-old preparations. The hippocampus, inferior colliculus and cerebral cortex were the only brain regions affected, presenting a mixed inflammatory-oxidative mechanism. Glutamate excitotoxicity was appreciable in only the hippocampus and inferior colliculus. Single drug treatment (indomethacin, curcumin, MgCl
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