ArticleScientific reports2017
Lasing in Live Mitotic and Non-Phagocytic Cells by Efficient Delivery of Microresonators.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Two-Photon 3D Printing of Functional Microstructures Inside Living Cells.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Wideband Tuning and Deep-Tissue Spectral Detection of Indium Phosphide Nano-Laser Particles.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Large-scale combinatorial optical barcoding of cells with laser particles.Light, science & applications · 2025Article
- Hyperspectral confocal imaging for high-throughput readout and analysis of bio-integrated microlasers.Nature protocols · 2024Review
- Intracellular biocompatible hexagonal boron nitride quantum emitters as single-photon sources and barcodes.Nanoscale · 2024Article
- Microcavity- and Microlaser-Based Optical Barcoding: A Review of Encoding Techniques and Applications.ACS photonics · 2023Review
- Article
- Laser particle activated cell sorting in microfluidics.Lab on a chip · 2022Article
- Monitoring Various Bioactivities at the Molecular, Cellular, Tissue, and Organism Levels via Biological Lasers.Sensors (Basel, Switzerland) · 2022Review
- Red-Shifted Excitation and Two-Photon Pumping of Biointegrated GaInP/AlGaInP Quantum Well Microlasers.ACS photonics · 2022Article
- Cellular Features Revealed by Transverse Laser Modes in Frequency Domain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Paradigm shift in future biophotonics for imaging and therapy: Miniature living lasers to cellular scale optoelectronics.Theranostics · 2022Review
- Biophotonic probes for bio-detection and imaging.Light, science & applications · 2021Review
- Whispering-gallery microlasers for cell tagging and barcoding: the prospects for in vivo biosensing.Light, science & applications · 2021Article
- Review of biosensing with whispering-gallery mode lasers.Light, science & applications · 2021Review
- Non-obstructive intracellular nanolasers.Nature communications · 2018Article
- Microsphere-based interferometric optical probe.Nature communications · 2018Article
- Spectral reading of optical resonance-encoded cells in microfluidics.Lab on a chip · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reliable methods to individually track large numbers of cells in real time are urgently needed to advance our understanding of important biological processes like cancer metastasis, neuronal network development and wound healing. It has recently been suggested to introduce microscopic whispering gallery mode lasers into the cytoplasm of cells and to use their characteristic, size-dependent emission spectrum as optical barcode but so far there is no evidence that this approach is generally applicable. Here, we describe a method that drastically improves intracellular delivery of resonators for several cell types, including mitotic and non-phagocytic cells. In addition, we characterize the influence of resonator size on the spectral characteristics of the emitted laser light and identify an optimum size range that facilitates tagging and tracking of thousands of cells simultaneously. Finally, we observe that the microresonators remain internalized by cells during cell division, which enables tagging several generations of cells.
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Registered trials
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