ArticleScientific reports2017
Systemic regulation of L-carnitine in nutritional metabolism in zebrafish, Danio rerio.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- The effect of L-carnitine supplementation on serum leptin concentrations: a systematic review and meta-analysis of randomized controlled trials.Endocrine · 2018Pooled it
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- Elevated phagocytic capacity directs innate spinal cord repair.Cell reports · 2026Article
- Protein levels alter yak rumen microbiota profiles, meat properties, and longissimus dorsi metabolites.Animal bioscience · 2026Article
- Intestine-derived sorbitol drives steatotic liver disease in the absence of gut bacteria.Science signaling · 2025Article
- Dietary L-carnitine supplementation recovers the hepatic damage induced by high-fat diet in Nile tilapia (Oreochromis niloticus L.) via activation of Nrf2/Keap pathway and inhibition of pro-inflammatory cytokine.Fish physiology and biochemistry · 2025Article
- L-carnitine: new perspectives on the management of preterm infants.Frontiers in nutrition · 2025Review
- L-Carnitine Improves Muscle Nutrient Metabolism and Intestinal Health in High-Fat-Fed Carp (Aquaculture nutrition · 2025Article
- Pparα activation stimulates autophagic flux through lipid catabolism-independent route.Fish physiology and biochemistry · 2024Article
- Amino Acid Requirements for Nile Tilapia: An Update.Animals : an open access journal from MDPI · 2023Review
- Article
- Evaluation of polyherbal formulation in broilers fed high energy diet: Implications on zootechnical parameters, fat accretion, and serum L-carnitine levels.Journal of advanced veterinary and animal research · 2022Article
- Effect of Adding L-carnitine to High-Fat/Low-Protein Diets of Common Carp (Aquaculture nutrition · 2022Article
- Editorial: Nutritional Management for the Energy Metabolism in Animals.Frontiers in veterinary science · 2022Article
- Suitable ratio of dietary L-carnitine and α-ketoglutarate improves growth and health performance in Nile tilapia, Oreochromis niloticus.Fish physiology and biochemistry · 2021Article
- Cascading Effects of Root Microbial Symbiosis on the Development and Metabolome of the Insect HerbivoreMetabolites · 2021Article
- Isotope tracing in adult zebrafish reveals alanine cycling between melanoma and liver.Cell metabolism · 2021Article
- Article
- The reduction of lipid-sourced energy production caused by ATGL inhibition cannot be compensated by activation of HSL, autophagy, and utilization of other nutrients in fish.Fish physiology and biochemistry · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excess fat accumulation has been observed widely in farmed fish; therefore, efficient lipid-lowering factors have obtained high attention in the current fish nutrition studies. Dietary L-carnitine can increase fatty acid β-oxidation in mammals, but has produced contradictory results in different fish species. To date, the mechanisms of metabolic regulation of L-carnitine in fish have not been fully determined. The present study used zebrafish to investigate the systemic regulation of nutrient metabolism by dietary L-carnitine supplementation. L-carnitine significantly decreased the lipid content in liver and muscle, accompanied by increased concentrations of total and free carnitine in tissues. Meanwhile, L-carnitine enhanced mitochondrial β-oxidation activities and the expression of carnitine palmitoyltransferase 1 mRNA significantly, whereas it depressed the mRNA expression of adipogenesis-related genes. In addition, L-carnitine caused higher glycogen deposition in the fasting state, and increased and decreased the mRNA expressions of gluconeogenesis-related and glycolysis-related genes, respectively. L-carnitine also increased the hepatic expression of mTOR in the feeding state. Taken together, dietary L-carnitine supplementation decreased lipid deposition by increasing mitochondrial fatty acid β-oxidation, and is likely to promote protein synthesis. However, the L-carnitine-enhanced lipid catabolism would cause a decrease in glucose utilization. Therefore, L-carnitine has comprehensive effects on nutrient metabolism in fish.
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