ArticleScientific reports2017
Novel Bio-functional Magnesium Coating on Porous Ti6Al4V Orthopaedic Implants: In vitro and In vivo Study.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 67 citations in OpenAlex.
- Article
- Magnesium ion implantation enhances the osseointegration and vascularization of 3D-Printed CoCrMo alloy scaffolds for load-bearing orthopedic applications.Bioactive materials · 2026Article
- Functional design of anastomotic staples in gastrointestinal surgery: mechanistic insights and clinical translation.Biomedical engineering online · 2026Review
- 3D printed porous magnesium metal scaffolds with bioactive coating for bone defect repair: enhancing angiogenesis and osteogenesis.Journal of nanobiotechnology · 2025Article
- Nanoparticles as Drug Delivery Carrier-synthesis, Functionalization and Application.Current pharmaceutical design · 2025Review
- What to Know about Antimicrobial Coatings in Arthroplasty: A Narrative Review.Medicina (Kaunas, Lithuania) · 2024Review
- Preparation of a novel antibacterial magnesium carbonate coating on a titanium surface and itsRSC advances · 2024Article
- In Vitro and In Vivo Applications of Magnesium-Enriched Biomaterials for Vascularized Osteogenesis in Bone Tissue Engineering: A Review of Literature.Journal of functional biomaterials · 2023Review
- Surface coating of orthopedic implant to enhance the osseointegration and reduction of bacterial colonization: a review.Biomaterials research · 2022Review
- Research status of biodegradable metals designed for oral and maxillofacial applications: A review.Bioactive materials · 2021Review
- Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK/mTOR/ULK1 signaling pathway.Materials today. Bio · 2021Article
- An animal model of early-stage femoral head osteonecrosis induced by cryo-insult in small tailed Han sheep.Journal of orthopaedic translation · 2021Article
- Biofunctional magnesium coated Ti6Al4V scaffold enhances osteogenesis and angiogenesisBioactive materials · 2020Article
- Comprehensive Evaluation of the Biological Properties of Surface-Modified Titanium Alloy Implants.Journal of clinical medicine · 2020Article
- Antibacterial Properties of Charged TiN Surfaces for Dental Implant Application.ChemistrySelect · 2019Article
- The relative effects of Ca and Mg ions on MSC osteogenesis in the surface modification of microrough Ti implants.International journal of nanomedicine · 2019Article
- Biofunctional Mg coating on PEEK for improving bioactivity.Bioactive materials · 2018Article
- E7 peptide-functionalized Ti6Al4V alloy for BMSC enrichment in bone tissue engineering.American journal of translational research · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Titanium and its alloys with various porous structures are one of the most important metals used in orthopaedic implants due to favourable properties as replacement for hard tissues. However, surface modification is critical to improve the osteointegration of titanium and its alloys. In this study, a bioactive magnesium coating was successfully fabricated on porous Ti6Al4V by means of arc ion plating, which was proved with fine grain size and high film/substrate adhesion. The surface composition and morphology were characterized by X-ray diffraction and SEM equipped with energy dispersive spectroscopy. Furthermore, the in vitro study of cytotoxicity and proliferation of MC3T3-E1 cells showed that magnesium coated porous Ti6Al4V had suitable degradation and biocompatibility. Moreover, the in vivo studies including fluorescent labelling, micro-computed tomography analysis scan and Van-Gieson staining of histological sections indicated that magnesium coated porous Ti6Al4V could significantly promote bone regeneration in rabbit femoral condylar defects after implantation for 4 and 8 weeks, and has better osteogenesis and osteointegration than the bare porous Ti6Al4V. Therefore, it is expected that this bioactive magnesium coating on porous Ti6Al4V scaffolds with improved osteointegration and osteogenesis functions can be used for orthopedic applications.
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