ReviewNature2017
From morphogen to morphogenesis and back.
Review in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
138 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dynamic changes in ocular shape during human development and its implications for retina fovea formation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024Pooled it
- Ectoderm tensile stress controls mesoderm internalization during embryo gastrulation.Nature communications · 2026Article
- In situ graphene-seq: spatial transcriptomics and chronic electrophysiological characterization of tissue microenvironments.Nature communications · 2026Article
- Cell differentiation can underpin the reproducibility of morphogenesis.PLoS computational biology · 2026Article
- Network hypermotifs in biological systems: structure, dynamics, and functional implications.NPJ systems biology and applications · 2026Review
- Pri micropeptide functions as a cell-intrinsic timer controlling the transient phase of cell fate induction.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- MultiCell: geometric learning in multicellular development.Nature methods · 2026Article
- Morphogen Gradients as Drivers of Mosaicism During Early Human Development.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Spatial patterning of contractility by a self-organized mechanogen activity gradient underlies Drosophila gastrulation.Nature communications · 2026Article
- BMP4 initiates and patterns ventral-caudal structures in zebrafish and human pluripotent stem cell aggregates.The EMBO journal · 2026Article
- Preventing hypocontractility-induced fibroblast expansion alleviates dilated cardiomyopathy.Science (New York, N.Y.) · 2025Article
- Cell jamming transitions can affect regulatory protein gradients and prime evolutionary divergence.Journal of the Royal Society, Interface · 2025Article
- Sociohydrodynamics: Data-driven modeling of social behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Planer-polarized junction association of the RacGEF ELMO-Sponge contributes to planar polarity and germband extension in Drosophila embryos.Science China. Life sciences · 2025Article
- Coping with uncertainty: Challenges for robust pattern formation in dynamical tissues.Seminars in cell & developmental biology · 2025Review
- Endogenous OptoRhoGEFs reveal biophysical principles of epithelial tissue furrowing.Nature communications · 2025Article
- Supracellular actomyosin assemblies: master coordinators of development.Development (Cambridge, England) · 2025Review
- Highly dynamic mechanical transitions in embryonic cell populations during Drosophila gastrulation.Nature communications · 2025Article
- A multi-tiered mechanical mechanism shapes the early neural plate.Nature communications · 2025Article
- Hepatic stellate cells: balancing homeostasis, hepatoprotection and fibrogenesis in health and disease.Nature reviews. Gastroenterology & hepatology · 2025Review
78 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A long-term aim of the life sciences is to understand how organismal shape is encoded by the genome. An important challenge is to identify mechanistic links between the genes that control cell-fate decisions and the cellular machines that generate shape, therefore closing the gap between genotype and phenotype. The logic and mechanisms that integrate these different levels of shape control are beginning to be described, and recently discovered mechanisms of cross-talk and feedback are beginning to explain the remarkable robustness of organ assembly. The 'full-circle' understanding of morphogenesis that is emerging, besides solving a key puzzle in biology, provides a mechanistic framework for future approaches to tissue engineering.
Indexed as
Identifiers
28102269What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.