ArticleScientific reports2017
Tracking of Mesenchymal Stem Cells with Fluorescence Endomicroscopy Imaging in Radiotherapy-Induced Lung Injury.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06021067 (Dead Mesenchymal Stem Cells for the Treatment of Radiation Lung Injury), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dead Mesenchymal Stem Cells for the Treatment of Radiation Lung Injury
Who cites it
17 citing papers in PubMed.
- Article
- Mesenchymal stem cells in radiation-induced lung injury: From mechanisms to therapeutic potential.Frontiers in cell and developmental biology · 2022Review
- The Radiation-Induced Regenerative Response of Adult Tissue-Specific Stem Cells: Models and Signaling Pathways.Cancers · 2021Review
- Article
- Nanoparticles for Stem Cell Tracking and the Potential Treatment of Cardiovascular Diseases.Frontiers in cell and developmental biology · 2021Review
- NoninvasiveWorld journal of stem cells · 2020Review
- Radioactive Labeling of Milk-Derived Exosomes withNanomaterials (Basel, Switzerland) · 2020Article
- Image computing for fibre-bundle endomicroscopy: A review.Medical image analysis · 2020Review
- In Vivo Endomicroscopy of Lung Injury and Repair in ARDS: Potential Added Value to Current Imaging.Journal of clinical medicine · 2019Review
- Functional endoscopy techniques for tracking stem cell fate.Quantitative imaging in medicine and surgery · 2019Review
- Radiation-Induced Lung Injury (RILI).Frontiers in oncology · 2019Review
- Mesenchymal stem cells for hemorrhagic stroke: status of preclinical and clinical research.NPJ Regenerative medicine · 2019Review
- Mesenchymal Stem Cells: Miraculous Healers or Dormant Killers?Stem cell reviews and reports · 2018Article
- Concise Review: Mesenchymal Stem Cell-Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise.Stem cells translational medicine · 2018Review
- Distinguishing between whole cells and cell debris using surface plasmon coupled emission.Biomedical optics express · 2018Article
- Image-Guided Fluorescence Endomicroscopy: From Macro- to Micro-Imaging of Radiation-Induced Pulmonary Fibrosis.Scientific reports · 2017Article
- A comparative analysis of longitudinal computed tomography and histopathology for evaluating the potential of mesenchymal stem cells in mitigating radiation-induced pulmonary fibrosis.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Mesenchymal stem cells (MSCs) have potential for reducing inflammation and promoting organ repair. However, limitations in available techniques to track them and assess this potential for lung repair have hindered their applicability. In this work, we proposed, implemented and evaluated the use of fluorescence endomicroscopy as a novel imaging tool to track MSCs in vivo. MSCs were fluorescently labeled and injected into a rat model of radiation-induced lung injury via endotracheal (ET) or intravascular (IV) administration. Our results show that MSCs were visible in the lungs with fluorescence endomicroscopy. Moreover, we developed an automatic cell counting algorithm to quantify the number of detected cells in each condition. We observed a significantly higher number of detected cells in ET injection compared to IV and a slight increase in the mean number of detected cells in irradiated lungs compared to control, although the latter did not reach statistical significance. Fluorescence endomicroscopy imaging is a powerful new minimally invasive and translatable tool that can be used to track and quantify MSCs in the lungs and help assess their potential in organ repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.