ReviewThe Lancet. Neurology2017
Pleiotropic genetic effects influencing sleep and neurological disorders.
Review in The Lancet. Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 65 citations in OpenAlex.
- Mendelian randomization analysis of the causal relationship between allergic rhinitis and depression and underlying mediation mechanisms.The World Allergy Organization journal · 2026Article
- Poor sleep is robustly correlated with accelerated aging but the evidence for causation is mixed.medRxiv : the preprint server for health sciences · 2026Article
- Polygenic Index for Sleep Duration and Brain Changes over Time.Medical sciences (Basel, Switzerland) · 2026Article
- Current Evidence for Sleep States inCurrent sleep medicine reports · 2026Review
- Article
- Circadian Regulation of Neuronal Membrane Capacitance-Mechanisms and Implications for Neural Computation and Behavior.International journal of molecular sciences · 2025Review
- A Pilot Study of Primary Ciliary Dyskinesia: Sleep-Related Disorders and Neuropsychiatric Comorbidities.Journal of clinical medicine · 2025Article
- Sleep and Autism: Current Research, Clinical Assessment, and Treatment Strategies.Focus (American Psychiatric Publishing) · 2024Article
- Behavioral and genetic correlates of heterogeneity in learning performance in individual honeybees, Apis mellifera.PloS one · 2024Article
- Evo-devo applied to sleep research: an approach whose time has come.Sleep advances : a journal of the Sleep Research Society · 2024Review
- Polygenic predisposition, sleep duration, and depression: evidence from a prospective population-based cohort.Translational psychiatry · 2023Article
- Pleiotropic effects of a high confidence Autism Spectrum Disorder gene,Neurobiology of sleep and circadian rhythms · 2023Article
- Multimodal assessment of circadian sleep health in predicting mental health outcomes in adolescents.Frontiers in sleep · 2023Article
- Investigating the contributions of circadian pathway and insomnia risk genes to autism and sleep disturbances.Translational psychiatry · 2022Article
- Influence of DNA-Polymorphisms in Selected Circadian Clock Genes on Clock Gene Expression in Subjects from the General Population and Their Association with Sleep Duration.Medicina (Kaunas, Lithuania) · 2022Article
- Calculating genetic risk for dysfunction in pleiotropic biological processes using whole exome sequencing data.Journal of neurodevelopmental disorders · 2022Article
- Article
- Synaptic dysfunction connects autism spectrum disorder and sleep disturbances: A perspective from studies in model organisms.Sleep medicine reviews · 2022Review
- Possible Neuropathology of Sleep Disturbance Linking to Alzheimer's Disease: Astrocytic and Microglial Roles.Frontiers in cellular neuroscience · 2022Review
- The dihydropyrimidine dehydrogenase gene contributes to heritable differences in sleep in mice.Current biology : CB · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Research evidence increasingly points to the large impact of sleep disturbances on public health. Many aspects of sleep are heritable and genes influencing traits such as timing, EEG characteristics, sleep duration, and response to sleep loss have been identified. Notably, large-scale genome-wide analyses have implicated numerous genes with small effects on sleep timing. Additionally, there has been considerable progress in the identification of genes influencing risk for some neurological sleep disorders. For restless legs syndrome, implicated variants are typically in genes associated with neuronal development. By contrast, genes conferring risk for narcolepsy function in the immune system. Many genetic variants associated with sleep disorders are also implicated in neurological disorders in which sleep abnormalities are common; for example, variation in genes involved in synaptic homoeostasis are implicated in autism spectrum disorder and sleep-wake control. Further investigation into pleiotropic roles of genes influencing both sleep and neurological disorders could lead to new treatment strategies for a variety of sleep disturbances.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.