ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2017
In Patients with a Soft Pancreas, a Thick Parenchyma, a Small Duct, and Fatty Infiltration Are Significant Risks for Pancreatic Fistula After Pancreaticoduodenectomy.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Postoperative pancreatic fistula: a bibliometric analysis of research trends and a meta-analysis on the association with intra pancreatic fat deposition.Scientific reports · 2025Pooled it
- A Simple Classification of Pancreatic Duct Size and Texture Predicts Postoperative Pancreatic Fistula: A classification of the International Study Group of Pancreatic Surgery.Annals of surgery · 2023Pooled it
- Risk factors for exocrine pancreatic insufficiency after pancreatic surgery: a systematic review and meta-analysis.Canadian journal of surgery. Journal canadien de chirurgiePooled it
- Thick pancreas, dense duct branching, and limited fibrosis as risk factors for pancreatic fistula after distal pancreatectomy.BMC gastroenterology · 2026Article
- Skin-to-portal junction distance as a simple CT-based predictor of pancreatic fistula after pancreaticoduodenectomy: a validated model.Updates in surgery · 2026Article
- Risk Factors for Postoperative Pancreatic Fistula After Pancreaticoduodenectomy: A Single-Center Experience.Cureus · 2026Article
- Assessing postoperative pancreatic fistula risk: from subjective assessment to digital pathology-assisted quantitative precision.Gland surgery · 2026Article
- Correlation between inflammation, vascularization, adipocyte percentage and exocrine cell percentage at the resection margin and the postoperative pancreatic fistula rate after distal pancreatectomy.Langenbeck's archives of surgery · 2026Article
- Feasibility and histological basis of predicting post-operative pancreatic fistula by pre-operative shear wave elastography: a prospective study.BMC gastroenterology · 2025Article
- Preoperative Endoscopic Ultrasound Strain Elastography Has Limited Value for Predicting Intraoperative Pancreatic Texture: A Single-Operator Pilot Study.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Estimation of pancreatic histology and likelihood of postoperative pancreatic fistula using extracellular volume fraction from contrast-enhanced computed tomography.World journal of clinical cases · 2025Article
- Efficacy of Chen's pancreaticojejunostomy for patients with soft pancreatic texture and small main pancreatic duct in laparoscopic pancreaticoduodenectomy.BMC surgery · 2025Article
- Development and validation of a nomogram based on preoperative factors for predicting clinically relevant postoperative pancreatic fistula following pancreaticoduodenectomy.Gland surgery · 2025Article
- Middle Pancreatectomy for Traumatic Main Pancreatic Duct Injury with Delayed Presentation: Two Case Series.Surgical case reports · 2025Article
- Tapering-pressure VAC therapy for wound exudation in POPF after pancreatoduodenectomy: a single-center experience.Frontiers in surgery · 2025Article
- Impact of Modified Blumgart Anastomosis on Pancreatic Fistula and Pancreaticojejunostomy Time During Laparoscopic Pancreaticoduodenectomy: Single-Center Experience.Journal of clinical medicine · 2024Article
- Extracellular volume fraction derived from dual-energy CT: a potential predictor for acute pancreatitis after pancreatoduodenectomy.European radiology · 2024Article
- Impact of pancreatic ductal occlusion on postoperative outcomes in pancreatic head cancer patients undergoing neoadjuvant therapy.Journal of gastroenterology · 2024Article
- Risk factors of textbook outcome in laparoscopic pancreatoduodenectomy: results from a prospective high-volume center study.BMC surgery · 2024Article
- A Comparison of Preoperative Predictive Scoring Systems for Postoperative Pancreatic Fistula after Pancreaticoduodenectomy Based on a Single-Center Analysis.Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study sought to characterize soft and hard pancreatic textures radiologically and histologically, and to identify specific risks in a soft pancreas associated with postoperative pancreatic fistula (POPF) formation after pancreaticoduodenectomy (PD).
methodsConsecutive 145 patients who underwent PD at a single institution between January 2010 and May 2013 were studied. Pancreatic consistency was intraoperatively judged as soft or hard. Pancreatic configuration was assessed using preoperative CT. Histologic components of the pancreatic stump were evaluated using a morphometric analysis. Clinicopathologic parameters were then analyzed for the risk of clinically relevant POPF.
resultsCompared with patients with a hard pancreas (n = 66), those with a soft pancreas (n = 79) had a smaller main pancreatic duct (MPD) diameter and a larger parenchymal thickness on CT, had a smaller fibrosis ratio and a larger lobular ratio histologically, and developed clinically relevant POPF more frequently (P < 0.001 for all). In patients with a soft pancreas, an MPD diameter <2 mm, a parenchymal thickness ≥10 mm, a lobular ratio <75%, and a fat ratio ≥20% were independently associated with clinically relevant POPF (P < 0.010 for all).
conclusionIn patients with a soft pancreas, a thick parenchyma, a small MPD, and fatty infiltration were strongly associated with clinically relevant POPF after PD.
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