ArticleEuropean journal of clinical pharmacology2017
Levodopa/carbidopa microtablets in Parkinson's disease: a study of pharmacokinetics and blinded motor assessment.
Article in European journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- NLX-112 Randomized Phase 2A Trial: Safety, Tolerability, Anti-Dyskinetic, and Anti-Parkinsonian Efficacy.Movement disorders : official journal of the Movement Disorder Society · 2025Trial
- Wearable sensors for monitoring drug pharmacokinetics in patients with Parkinson's disease.Scientific reports · 2026Article
- Non-invasive, continuous oral delivery of solid levodopa-carbidopa for management of Parkinson's disease.Scientific reports · 2024Article
- Revolutionizing Precision Medicine: Exploring Wearable Sensors for Therapeutic Drug Monitoring and Personalized Therapy.Biosensors · 2023Review
- Negative pressure pulmonary edema due to upper airway obstruction after general anesthesia in a patient with Parkinson's disease: A case report.Clinical case reports · 2023Article
- Personalized Medicine Approach in Treating Parkinson's Disease, Using Oral Administration of Levodopa/Carbidopa Microtablets in Clinical Practice.Journal of personalized medicine · 2021Article
- Initial Experience of the Levodopa-Entacapone-Carbidopa Intestinal Gel in Clinical Practice.Journal of personalized medicine · 2021Article
- Automatic Resting Tremor Assessment in Parkinson's Disease Using Smartwatches and Multitask Convolutional Neural Networks.Sensors (Basel, Switzerland) · 2021Article
- Characterization, passive and active treatment in strabismic amblyopia: a narrative review.International journal of ophthalmology · 2020Review
- Chitosan-Coated Hydroxypropylmethyl Cellulose Microparticles of Levodopa (and Carbidopa): In Vitro and Rat Model Kinetic Characteristics.Current therapeutic research, clinical and experimental · 2020Article
- Sensor-based algorithmic dosing suggestions for oral administration of levodopa/carbidopa microtablets for Parkinson's disease: a first experience.Journal of neurology · 2019Article
- Population pharmacokinetics of levodopa/carbidopa microtablets in healthy subjects and Parkinson's disease patients.European journal of clinical pharmacology · 2018Article
- Individualization of levodopa treatment using a microtablet dispenser and ambulatory accelerometry.CNS neuroscience & therapeutics · 2018Observational
- Verification of a Method for Measuring Parkinson's Disease Related Temporal Irregularity in Spiral Drawings.Sensors (Basel, Switzerland) · 2017Article
- Development of new levodopa treatment strategies in Parkinson's disease-from bedside to bench to bedside.Upsala journal of medical sciences · 2017Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMotor function assessments with rating scales in relation to the pharmacokinetics of levodopa may increase the understanding of how to individualize and fine-tune treatments.
objectivesThis study aimed to investigate the pharmacokinetic profiles of levodopa-carbidopa and the motor function following a single-dose microtablet administration in Parkinson's disease.
methodsThis was a single-center, open-label, single-dose study in 19 patients experiencing motor fluctuations. Patients received 150% of their individual levodopa equivalent morning dose in levodopa-carbidopa microtablets. Blood samples were collected at pre-specified time points. Patients were video recorded and motor function was assessed with six UPDRS part III motor items, dyskinesia score, and the treatment response scale (TRS), rated by three blinded movement disorder specialists.
resultsAUC
conclusionsIn the PD population, following levodopa/carbidopa microtablet administration in fasting state, the C
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.