GuidelineIntensive care medicine2017
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.
34 registry-linked trialsAbstract readConsensus StatementPractice Guideline
In one paragraph
Guideline in Intensive care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 34 registered trials, which are not on this map. Cited by 2,781 papers, 10 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
2,781citing papers in PubMed, 10 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Southern Medical University Clinical Research Project Initiative：Efficacy and Safety of a Multicomponent Physical Therapy Program in Mechanically Ventilated Patient With Sepsis
Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis.
Guided Fluid-balance Optimization With Mini-fluid chALlenge During Septic Shock: A Multicenter, Stepped Wedge Cluster Randomized Trial
Mortality Due to Septic Shock Associated With Thrombocytopenia in the Intensive Care Unit
Procalcitonin to Guide Antibiotic Stop in Neurocritical Care Patients. An Interventional Matched-cohort Study.
Improving Morbidity During Post-Acute Care Transitions for Sepsis (IMPACTS): A Pragmatic Randomized Evaluation of Implementing Best Practice Care for Sepsis Survivors to Reduce Morbidity and Mortality
ROle of Dexmedetomidine in Modifying Immune Paralysis In Patient With Septic Shock: Randomized Controlled Trial (RODIS Trial)
PILOT STUDY in the Use of Therapeutic Plasma Exchange in Adult Patients With Severe Sepsis
Fast Assay for Pathogen Identification - Quasi-Experimental Intervention Study
Hemodynamic Resuscitation and Monitoring in Early Sepsis
Effectiveness of Fluid Deresuscitation With Central Venous Pressure Target 0-4 mmHg on Capillary Perfusion Density, Acute Kidney Injury Stage, Cardiac Index, and the Intensive Care Unit Length of Stay in Septic Shock Patients After Resuscitation
A Multicentre Concealed-Allocation Multi-arms Blinded Randomized Controlled Trial to Identify the Best Sepsis Population for Corticotherapy
Terlipressin Versus Placebo for Septic Shock Refractory to High Doses Catecholamine Vasopressors: A Randomized-controlled Trial
Comparative Study on the Relationship Between Fluid REsponsiveness and Arterial ELASTANCE in Patients With Septic Shock or in the Postoperative Course of Aortic Surgery
Evaluation of Tidal Volume Challenge to Detect Preload-responsiveness in Patients With Acute Respiratory Distress Syndrome (ARDS) During Prone Position
Implementation and Effectiveness of Engagement and Collaborative Management to Proactively Advance Sepsis Survivorship: A Hybrid Effectiveness-Implementation Randomized Controlled Trial
Treatment With Pirfenidone for COVID-19 Related Severe ARDS An Open Label Pilot Trial
Capillary Refill Time Response to a Rapid Fluid Challenge in Septic Shock Patients: Pathophysiological Determinants, and Relation to Changes in Systemic, Regional and Microcirculatory Blood Flow
Dosing of Extracorporeal Cytokine Removal In Septic Shock (DECRISS): a Prospective, Randomized, Multicenter Clinical Trial
Is TIme From adMission to surgEry an Independent Prognostic Factor for Survival of Patients With Gastro-intestinal Perforation Associated With Septic Shock: (TIME) An Italian Intersocietary Retrospective and Prospective Observational Trial
Innovative Solutions to Organ-substituting Technologies in the Treatment of Heart and Pulmonary Failure
Development of Innovative Technologies for the Treatment of Pulmonary and Heart Failure to Prolong Human's Life
Effect of Antibiotic Choice On ReNal Outcomes (ACORN)
CLinical Efficacy of Hemoperfusion With a Cytokine Adsorber in Norepinephrine-Resistant SEptic Shock
Association of Respiratory Variation of Superior Vena Cava in Transthoracic View and Fluid Responsiveness in Critically Ill Patients
Effect of High-Flow Nasal Cannula on IVC Measurements Using Point of Care Ultrasound
Lectro-acupuncture at Zusanli, Qihai, and Guanyuan Acupoints Regulate Immune Function in Patients With Sepsis
Is the Ratio of Optic Nerve Sheath Diameter to Eyeball Transverse Diameter Correlated with the Prognosis of Sepsis Associated Encephalopathy in Critically Ill Patients
C-Reactive Protein / Albumin Ratio as a Predictive Inflammatory Marker for Postoperative Systemic Inflammatory Response Syndrome and/or Sepsis in Polytraumatized Patients in ICU
Effect of Direct-from-blood Bacterial Testing on Antibiotic Administration and Clinical Outcomes: A Learning Healthcare Pragmatic Randomized Trial
Effect of Vasopressin on Kidney and Cardiac Function in Previously Hypertensive Patients With Septic Shock: A Randomized Clinical Trial
Markers of Nephrotoxicity During Treatment With Antibiotic Combinations: A Pragmatic Clinical Trial
Efficacy and Safety of Balanced Gelatin Solution for Fluid Infusion in Sepsis Patients Undergoing Emergency Abdominal Surgery: A Multicenter, Adaptive Designed, Randomized Controlled Trial
Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock: A Multicenter Prospective Randomized Trial (CARBON)
Who cites it
2,781 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Pooled it
- Efficacy and Safety of Procalcitonin-Guided Antibiotic Therapy versus Standard of Care for Sepsis: A Systematic Review and Meta-Analysis.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Pooled it
- Comparative efficacy of levosimendan and dobutamine in sepsis-related cardiac impairment: a meta-analysis.European journal of clinical pharmacology · 2026Pooled it
- Continuous versus Intermittent Hydrocortisone for the Treatment of Septic Shock: A Systematic Review and Meta-Analysis.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Pooled it
- New trends and hotspots in Sepsis-associated encephalopathy research: a bibliometric and visualization analysis.Frontiers in aging neuroscience · 2026Pooled it
- External validity limitations of randomized trials cited in adult critical care clinical practice guidelines: a systematic review of guidelines published from 2015 to 2020.Frontiers in medicine · 2026Pooled it
- Efficacy and safety of acupuncture for septic gastrointestinal dysfunction: a systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2026Pooled it
- Efficacy and safety of erythromycin and metoclopramide, alone or in combination, for successful feeding in critically Ill patients: a systematic review and network meta-analysis.Frontiers in nutrition · 2026Pooled it
- Risk factors for nosocomial infections in ECMO patients: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Prognostic value of monocyte chemoattractant protein-1 in sepsis: a systematic review and meta-analysis.BMC immunology · 2025Pooled it
- [Application and comparative study of critical care ultrasound and noninvasive cardiac output monitoring in fluid resuscitation of neonatal septic shock: a randomized controlled trial].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Trial
- Restrictive Versus Standard Intravenous Fluid Therapy and Endothelial Glycocalyx Shedding in ICU Patients With Septic Shock-A Preplanned Sub-Study of the Randomized CLASSIC Trial.Acta anaesthesiologica Scandinavica · 2026Trial
- Identification of novel sepsis-related neutrophil subsets and surface markers for clinical diagnosis and outcome.Virulence · 2026Article
- Study on the Role of Galectin-3 in Sepsis.Biochemical genetics · 2026Article
- Prevalence of MRSA Bacteremia and Predictors of In-Hospital Mortality Among Critically Ill Adults in a Tanzanian Intensive Care Unit: A Retrospective Cross-Sectional Study.Health science reports · 2026Article
- URB597 attenuates experimental sepsis-associated acute kidney injury with reduced renal inflammation, apoptosis, and TLR4/NF-κB activation.Molecular biology reports · 2026Article
- Development and Validation of an Interpretable Machine Learning Model to Predict Mortality in Patients With Sepsis-Induced Coagulopathy: Multicenter Cohort Study.JMIR medical informatics · 2026Article
- Unfractionated Heparin and Low-Molecular-Weight Heparin in Sepsis: Anti-Inflammatory and Anticoagulant Effects Versus No Anticoagulation-A Propensity Score-Matched Analysis.Journal of clinical laboratory analysis · 2026Article
- Planning and performing CT-guided interventions for source control in septic patients: a survey by the European Society of Emergency Radiology.Insights into imaging · 2026Article
- Beyond the gut microbe: Rethinking infection, microbiome harmony, and the one-health continuum.World journal of gastrointestinal pharmacology and therapeutics · 2026Review
2,721 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
59 authors.
Andrew RhodesSt. George's Hospital, London, England, UK. andrewrhodes@nhs.net.
Laura E EvansNew York University School of Medicine, New York, NY, USA.
Waleed AlhazzaniMcMaster University, Hamilton, ON, Canada.
Mitchell M LevyBrown University School of Medicine, Providence, RI, USA.
Massimo AntonelliInstituto di Anestesiologia e Rianimazione, Università Cattolica del Sacro Cuore, Rome, Italy.
Ricard FerrerVall d'Hebron University Hospital, Barcelona, Spain.
Anand KumarUniversity of Manitoba, Winnipeg, MB, Canada.
Jonathan E SevranskyEmory University Hospital, Atlanta, GA, USA.
Charles L SprungHadassah Hebrew University Medical Center, Jerusalem, Israel.
Mark E NunnallyNew York University School of Medicine, New York, NY, USA.
Bram RochwergMcMaster University, Hamilton, ON, Canada.
Gordon D RubenfeldSunnybrook Health Sciences Centre, Toronto, ON, Canada.
Derek C AngusUniversity of Pittsburgh Critical Care Medicine CRISMA Laboratory, Pittsburgh, PA, USA.
Djillali AnnaneHospital Raymond Poincare, Garches, France.
Richard J BealeSaint Thomas Hospital, London, England, UK.
Geoffrey J BellinghanUniversity College London Hospitals, London, England, UK.
Gordon R BernardVanderbilt University Medical Center, Nashville, TN, USA.
Jean-Daniel ChicheService de Reanimation Medicale, Paris, France.
Craig CoopersmithEmory University Hospital, Atlanta, GA, USA.
Daniel P De BackerCHIREC Hospitals, Braine L'Alleud, Belgium.
Craig J FrenchWestern Hospital, Victoria, Australia.
Seitaro FujishimaKeio University School of Medicine, Tokyo, Japan.
Herwig GerlachVivantes-Klinikum Neukölln, Berlin, Germany.
Jorge Luis HidalgoKarl Heusner Memorial Hospital, Belize Healthcare Partners, Belize City, Belize.
Steven M HollenbergCooper Health System, Camden, NJ, USA.
Alan E JonesUniversity of Mississippi Medical Center, Jackson, MS, USA.
Dilip R KarnadJupiter Hospital, Thane, India.
Ruth M KleinpellRush University Medical Center, Chicago, IL, USA.
Younsuk KohASAN Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Thiago Costa LisboaHospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.
Flavia R MachadoFederal University of Sao Paulo, Sao Paulo, Brazil.
John J MariniRegions Hospital, St. Paul, MN, USA.
John C MarshallSaint Michael's Hospital, Toronto, ON, Canada.
John E MazuskiWashington University School of Medicine, St. Louis, MO, USA.
Lauralyn A McIntyreOttawa Hospital, Ottawa, ON, Canada.
Anthony S McLeanNepean Hospital, University of Sydney, Penrith, NSW, Australia.
Sangeeta MehtaMount Sinai Hospital, Toronto, ON, Canada.
Rui P MorenoUCINC, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.
John MyburghUniversity of New South Wales, Sydney, NSW, Australia.
Paolo NavalesiUniversità dellla Magna Graecia, Catanzaro, Italy.
Osamu NishidaFujita Health University School of Medicine, Toyoake, Aich, Japan.
Tiffany M OsbornWashington University School of Medicine, St. Louis, MO, USA.
Anders PernerRigshospitalet, Copenhagen, Denmark.
Colleen M PlunkettRush University Medical Center, Chicago, IL, USA.
Marco RanieriUniversità Sapienza, Rome, Italy.
Christa A SchorrCooper Health System, Camden, NJ, USA.
Maureen A SeckelChristiana Care Health Services, Newark, DE, USA.
Christopher W SeymourUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Lisa ShiehStanford University School of Medicine, Stanford, CA, USA.
Khalid A ShukriKaust Medical Services, Thuwal, Saudi Arabia.
Steven Q SimpsonUniversity of Kansas Medical Center, Kansas City, KS, USA.
Mervyn SingerWolfson Institute of Biomedical Research, London, England, UK.
B Taylor ThompsonMassachusetts General Hospital, Boston, MA, USA.
Sean R TownsendCalifornia Pacific Medical Center, San Francisco, CA, USA.
Thomas Van der PollUniversity of Amsterdam, Amsterdam, Netherlands.
Jean-Louis VincentErasmé University Hospital, Brussels, Belgium.
W Joost WiersingaUniversity of Amsterdam, Amsterdam, Netherlands.
Janice L ZimmermanHouston Methodist Hospital, Houston, TX, USA.
R Phillip DellingerCooper Health System, Camden, NJ, USA.
Funding
Sepsis subtypes: biology, treatment, and bedside applicationR35GM119519 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Christopher W. Seymour · 2016 to 2026
$4.9MNIGMS NIH HHS R35 GM119519
Abstract
objectiveTo provide an update to "Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012".
designA consensus committee of 55 international experts representing 25 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict-of-interest (COI) policy was developed at the onset of the process and enforced throughout. A stand-alone meeting was held for all panel members in December 2015. Teleconferences and electronic-based discussion among subgroups and among the entire committee served as an integral part of the development.
methodsThe panel consisted of five sections: hemodynamics, infection, adjunctive therapies, metabolic, and ventilation. Population, intervention, comparison, and outcomes (PICO) questions were reviewed and updated as needed, and evidence profiles were generated. Each subgroup generated a list of questions, searched for best available evidence, and then followed the principles of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system to assess the quality of evidence from high to very low, and to formulate recommendations as strong or weak, or best practice statement when applicable.
resultsThe Surviving Sepsis Guideline panel provided 93 statements on early management and resuscitation of patients with sepsis or septic shock. Overall, 32 were strong recommendations, 39 were weak recommendations, and 18 were best-practice statements. No recommendation was provided for four questions.
conclusionsSubstantial agreement exists among a large cohort of international experts regarding many strong recommendations for the best care of patients with sepsis. Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality.
Indexed as
Anti-Bacterial AgentsBlood GlucoseCalcitoninCritical IllnessErythrocyte TransfusionFluid TherapyHumansNutrition AssessmentPatient Care PlanningRenal Replacement TherapyRespiration, ArtificialSepsisShock, SepticVasoconstrictor AgentsAnti-Bacterial AgentsBlood GlucoseCalcitoninVasoconstrictor AgentsEvidence-based medicineGrading of Recommendations Assessment, Development, and Evaluation criteriaGuidelinesInfectionSepsisSepsis bundlesSepsis syndromeSeptic shockSurviving Sepsis Campaign
Identifiers
PMID
28101605What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT03406494ClinicalTrials.gov
NCT03422159ClinicalTrials.gov
NCT03461900ClinicalTrials.gov
NCT03617965ClinicalTrials.gov
NCT03683693ClinicalTrials.gov
NCT03865602ClinicalTrials.gov
and 28 more above
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.