ArticleBiomedical optics express2017
Dynamic imaging and quantitative analysis of cranial neural tube closure in the mouse embryo using optical coherence tomography.
Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Discovering the unexpected: Insights into the dynamics of mouse neural tube closure revealed by time-lapse imaging.Developmental biology · 2026Review
- Dynamic Imaging of Mouse Embryos and Cardiodynamics in Static Culture.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Depth-Resolved Attenuation Coefficient Quantification During Murine Embryonic Brain Development.Journal of biophotonics · 2025Article
- Clipping spline: interactive, dynamic 4D volume clipping and analysis based on thin plate spline.Biomedical optics express · 2025Article
- Assessing the effects of prenatal poly-drug exposure on fetal brain vasculature using optical coherence angiography.Journal of biomedical optics · 2023Article
- Open-source, highly efficient, post-acquisition synchronization for 4D dual-contrast imaging of the mouse embryonic heart over development with optical coherence tomography.Biomedical optics express · 2023Article
- Focal Spinal Nondisjunctional Disorders: Including a Discussion on the Embryogenesis of Cranial Focal Nondisjunctional Lesions.Advances and technical standards in neurosurgery · 2023Review
- Multimodal imaging system combining optical coherence tomography and Brillouin microscopy for neural tube imaging.Optics letters · 2022Article
- Mouse embryo phenotyping with optical coherence tomography.Frontiers in cell and developmental biology · 2022Review
- Hindbrain neuropore tissue geometry determines asymmetric cell-mediated closure dynamics in mouse embryos.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Embryonic Mouse Cardiodynamic OCT Imaging.Journal of cardiovascular development and disease · 2020Review
- Live mechanistic assessment of localized cardiac pumping in mammalian tubular embryonic heart.Journal of biomedical optics · 2020Article
- Optical coherence tomography angiography to evaluate murine fetal brain vasculature changes caused by prenatal exposure to nicotine.Biomedical optics express · 2020Article
- Label-free optical imaging in developmental biology [Invited].Biomedical optics express · 2020Review
- Assessing the acute effects of prenatal synthetic cannabinoid exposure on murine fetal brain vasculature using optical coherence tomography.Journal of biophotonics · 2019Article
- Visualising the Cardiovascular System of Embryos of Biomedical Model Organisms with High Resolution Episcopic Microscopy (HREM).Journal of cardiovascular development and disease · 2018Review
- Evaluating the effects of maternal alcohol consumption on murine fetal brain vasculature using optical coherence tomography.Journal of biophotonics · 2018Article
- Comparison and combination of rotational imaging optical coherence tomography and selective plane illumination microscopy for embryonic study.Biomedical optics express · 2017Article
- Evaluating biomechanical properties of murine embryos using Brillouin microscopy and optical coherence tomography.Journal of biomedical optics · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Neural tube closure is a critical feature of central nervous system morphogenesis during embryonic development. Failure of this process leads to neural tube defects, one of the most common forms of human congenital defects. Although molecular and genetic studies in model organisms have provided insights into the genes and proteins that are required for normal neural tube development, complications associated with live imaging of neural tube closure in mammals limit efficient morphological analyses. Here, we report the use of optical coherence tomography (OCT) for dynamic imaging and quantitative assessment of cranial neural tube closure in live mouse embryos in culture. Through time-lapse imaging, we captured two neural tube closure mechanisms in different cranial regions, zipper-like closure of the hindbrain region and button-like closure of the midbrain region. We also used OCT imaging for phenotypic characterization of a neural tube defect in a mouse mutant. These results suggest that the described approach is a useful tool for live dynamic analysis of normal neural tube closure and neural tube defects in the mouse model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.