ArticleBiomedical optics express2017
Posterior rat eye during acute intraocular pressure elevation studied using polarization sensitive optical coherence tomography.
Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Polarization-Sensitive Optical Coherence Tomography Imaging of Posterior Staphyloma Edges in Eyes With High Myopia.Investigative ophthalmology & visual science · 2025Observational
- Posterior scleral birefringence measured by triple-input polarization-sensitive imaging as a biomarker of myopia progression.Nature biomedical engineering · 2023Article
- Molecular Contrast Optical Coherence Tomography and Its Applications in Medicine.International journal of molecular sciences · 2022Review
- Monitoring retinal responses to acute intraocular pressure elevation in rats with visible light optical coherence tomography.Neurophotonics · 2019Article
- Structured polarized light microscopy for collagen fiber structure and orientation quantification in thick ocular tissues.Journal of biomedical optics · 2018Article
- White light polarization sensitive optical coherence tomography for sub-micron axial resolution and spectroscopic contrast in the murine retina.Biomedical optics express · 2018Article
- Ocular fundus pulsations within the posterior rat eye: Chorioscleral motion and response to elevated intraocular pressure.Scientific reports · 2017Article
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Authors and funding
9 authors.
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Abstract
Polarization sensitive optical coherence tomography (PS-OCT) operating at 840 nm with axial resolution of 3.8 µm in tissue was used for investigating the posterior rat eye during an acute intraocular pressure (IOP) increase experiment. IOP was elevated in the eyes of anesthetized Sprague Dawley rats by cannulation of the anterior chamber. Three dimensional PS-OCT data sets were acquired at IOP levels between 14 mmHg and 105 mmHg. Maps of scleral birefringence, retinal nerve fiber layer (RNFL) retardation and relative RNFL/retina reflectivity were generated in the peripapillary area and quantitatively analyzed. All investigated parameters showed a substantial correlation with IOP. In the low IOP range of 14-45 mmHg only scleral birefringence showed statistically significant correlation. The polarization changes observed in the PS-OCT imaging study presented in this work suggest that birefringence of the sclera may be a promising IOP-related parameter to investigate.
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