Evidence map›Paper›PMID 28101415›Full record

ArticleBiomedical optics express2017

Endoscopic sensing of alveolar pH.

D Choudhury, M G Tanner, S McAughtrie, F Yu, B Mills, T R Choudhary, S Seth, T H Craven, J M Stone, I K Mati and 6 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04530448 (Coronavirus Induced Acute Kidney Injury), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04530448 phase4terminatednot on this mapstarted 2020, after this paper: background citation

Coronavirus Induced Acute Kidney Injury: Prevention Using Urine Alkalinization

TypeinterventionalSponsorWest Virginia UniversityRan2020 to 2021Enrolled3ConditionsCOVID, Coronavirus, Coronavirus Infection, AKIArmsSodium bicarbonate, Standard of Care
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

D ChoudhuryScottish Universities Physics Alliance (SUPA), Institute of Photonics and Quantum Sciences (IPaQS), Heriot-Watt University, Edinburgh, UK; EPSRC IRC Hub, MRC Centre for Inflammation Research, Queen's Medical Research Institute (QMRI), University of Edinburgh, Edinburgh, UK; These authors contributed equally to this work.
M G TannerScottish Universities Physics Alliance (SUPA), Institute of Photonics and Quantum Sciences (IPaQS), Heriot-Watt University, Edinburgh, UK; EPSRC IRC Hub, MRC Centre for Inflammation Research, Queen's Medical Research Institute (QMRI), University of Edinburgh, Edinburgh, UK; These authors contributed equally to this work.
S McAughtrieEPSRC IRC Hub, MRC Centre for Inflammation Research, Queen's Medical Research Institute (QMRI), University of Edinburgh, Edinburgh, UK; School of Chemistry, University of Edinburgh, Edinburgh, UK.
F YuCentre for Photonics and Photonic Materials, Department of Physics, University of Bath, Bath, UK.
B MillsEPSRC IRC Hub, MRC Centre for Inflammation Research, Queen's Medical Research Institute (QMRI), University of Edinburgh, Edinburgh, UK.
T R ChoudharyEPSRC IRC Hub, MRC Centre for Inflammation Research, Queen's Medical Research Institute (QMRI), University of Edinburgh, Edinburgh, UK; Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK.
S SethSchool of Informatics, University of Edinburgh, Edinburgh, UK.
T H CravenEPSRC IRC Hub, MRC Centre for Inflammation Research, Queen's Medical Research Institute (QMRI), University of Edinburgh, Edinburgh, UK; Pulmonary Molecular Imaging Group, MRC Centre for Inflammation Research, Queen's Medical Research Institute (QMRI), University of Edinburgh, Edinburgh, UK.
J M StoneCentre for Photonics and Photonic Materials, Department of Physics, University of Bath, Bath, UK.
I K MatiSchool of Chemistry, University of Edinburgh, Edinburgh, UK.
C J CampbellSchool of Chemistry, University of Edinburgh, Edinburgh, UK.
M BradleyEPSRC IRC Hub, MRC Centre for Inflammation Research, Queen's Medical Research Institute (QMRI), University of Edinburgh, Edinburgh, UK; School of Chemistry, University of Edinburgh, Edinburgh, UK.
C K I WilliamsSchool of Informatics, University of Edinburgh, Edinburgh, UK.
K DhaliwalEPSRC IRC Hub, MRC Centre for Inflammation Research, Queen's Medical Research Institute (QMRI), University of Edinburgh, Edinburgh, UK; Pulmonary Molecular Imaging Group, MRC Centre for Inflammation Research, Queen's Medical Research Institute (QMRI), University of Edinburgh, Edinburgh, UK.
T A BirksCentre for Photonics and Photonic Materials, Department of Physics, University of Bath, Bath, UK.
R R ThomsonScottish Universities Physics Alliance (SUPA), Institute of Photonics and Quantum Sciences (IPaQS), Heriot-Watt University, Edinburgh, UK; EPSRC IRC Hub, MRC Centre for Inflammation Research, Queen's Medical Research Institute (QMRI), University of Edinburgh, Edinburgh, UK.

Funding

Medical Research Council G0901697Medical Research Council MR/K017047/1Medical Research Council MR/L012766/1
6 · The paper itself

Abstract

Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a ~100-fold increase in SERS signal-to-fiber background ratio, and demonstrate multiple site pH sensing with a measurement accuracy of ± 0.07 pH units in the respiratory acini of an

Indexed as

(170.4580) Optical diagnostics for medicine(170.6510) Spectroscopy, tissue diagnostics

Identifiers

PMID28101415
PMCPMC5231296

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.