ArticleBiology of sex differences2017
Corticotropin-releasing factor overexpression in mice abrogates sex differences in body weight, visceral fat, and food intake response to a fast and alters levels of feeding regulatory hormones.
Article in Biology of sex differences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Pancreatic cancer: molecular pathogenesis and emerging therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Sex Differences in the Neuropeptide Y System and Implications for Stress Related Disorders.Biomolecules · 2020Review
- Sex-dependent effects of chronic variable stress on discrete corticotropin-releasing factor receptor 1 cell populations.Physiology & behavior · 2020Article
- A systematic review on different models of inducing obesity in animals: Advantages and limitations.Journal of advanced veterinary and animal research · 2020Review
- Corticotropin releasing factor-overexpressing mouse is a model of chronic stress-induced muscle atrophy.PloS one · 2020Article
- Sex differences in basal hypothalamic anorectic and orexigenic gene expression and the effect of quantitative and qualitative food restriction.Biology of sex differences · 2018Article
- Gut-Brain Neuroendocrine Signaling Under Conditions of Stress-Focus on Food Intake-Regulatory Mediators.Frontiers in endocrinology · 2018Review
- Non-clinical acute and chronic toxicity evaluations ofToxicology reports · 2018Article
- Isopropyl Caffeate: A Caffeic Acid Derivative-Antioxidant Potential and Toxicity.Oxidative medicine and cellular longevity · 2018Article
- Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential.Stress (Amsterdam, Netherlands) · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCorticotropin-releasing factor overexpressing (CRF-OE) male mice showed an inhibited feeding response to a fast, and lower plasma acyl ghrelin and Fos expression in the arcuate nucleus compared to wild-type (WT) mice. We investigated whether hormones and hypothalamic feeding signals are impaired in CRF-OE mice and the influence of sex.
methodsMale and female CRF-OE mice and WT littermates (4-6 months old) fed
resultsUnder fed conditions, compared to WT, CRF-OE mice have increased adrenal glands and perigonadal fat weight, plasma corticosterone, leptin and insulin, and hypothalamic leptin receptor and decreased plasma acyl ghrelin. Compared to male, female WT mice have lower body and perigonadal fat and plasma leptin but higher adrenal glands weights. CRF-OE mice lost these sex differences except for the adrenals. Male CRF-OE and WT mice did not differ in hypothalamic expression of neuropeptide Y (NPY) and proopiomelanocortin (POMC), while female CRF-OE compared to female WT and male CRF-OE had higher NPY mRNA levels. After fasting, female WT mice lost more body weight and ate more food than male WT, while CRF-OE mice had reduced body weight loss and inhibited food intake without sex difference. In male WT mice, fasting reduced plasma insulin and leptin and increased acyl ghrelin and corticosterone while female WT showed only a rise in corticosterone. In CRF-OE mice, fasting reduced insulin while leptin, acyl ghrelin and corticosterone were unchanged with no sex difference. Fasting blood glucose was higher in CRF-OE with female > male. In WT mice, fasting increased hypothalamic NPY expression in both sexes and decreased POMC only in males, while in CRF-OE mice, NPY did not change, and POMC decreased in males and increased in females.
conclusionsThese data indicate that CRF-OE mice have abnormal basal and fasting circulating hormones and hypothalamic feeding-related signals. CRF-OE also abolishes the sex difference in body weight, abdominal fat, and fasting-induced feeding and changes in plasma levels of leptin and acyl ghrelin.
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