ArticleExperimental and therapeutic medicine2016
miR-125a-3p targetedly regulates GIT1 expression to inhibit osteoblastic proliferation and differentiation.
Article in Experimental and therapeutic medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- lncRNA-Gm5532 regulates osteoclast differentiation through the miR-125a-3p/TRAF6 axis.Acta biochimica et biophysica Sinica · 2024Article
- Intraarticular treatment with integrin α10β1-selected mesenchymal stem cells affects microRNA expression in experimental post-traumatic osteoarthritis in horses.Frontiers in veterinary science · 2024Article
- Micro-RNAs: A safety net to protect hematopoietic stem cell self-renewal.Wiley interdisciplinary reviews. RNA · 2022Review
- miR‑125/CDK2 axis in cochlear progenitor cell proliferation.Molecular medicine reports · 2021Article
- miRNAs Related to Different Processes of Fracture Healing: An Integrative Overview.Frontiers in surgery · 2021Review
- Mechanisms of miR‑128‑3p in inhibiting osteoblast differentiation from bone marrow‑derived mesenchymal stromal cells.Molecular medicine reports · 2020Article
- Beneficial role of microRNA-328-3p in fracture healing by enhancing osteoblastic viability through the PTEN/PI3K/AKT pathway.Experimental and therapeutic medicine · 2020Article
- Differential expression of microRNAs in the hippocampi of male and female rodents after chronic alcohol administration.Biology of sex differences · 2020Article
- MiR-17-3p inhibits osteoblast differentiation by downregulating Sox6 expression.FEBS open bio · 2020Article
- MicroRNA-125a-3p participates in odontoblastic differentiation of dental pulp stem cells by targeting Fyn.Cytotechnology · 2020Article
- Roles of MicroRNAs in Bone Destruction of Rheumatoid Arthritis.Frontiers in cell and developmental biology · 2020Review
- miR-149-5p inhibits cell proliferation and invasion through targeting GIT1 in medullary thyroid carcinoma.Oncology letters · 2019Article
- MiR-125a-5p promotes osteoclastogenesis by targeting TNFRSF1B.Cellular & molecular biology letters · 2019Article
- MiR-125a-3p negatively regulates osteoblastic differentiation of human adipose derived mesenchymal stem cells by targeting Smad4 and Jak1.American journal of translational research · 2019Article
- Inhibiting GIT1 reduces the growth, invasion, and angiogenesis of osteosarcoma.Cancer management and research · 2018Article
- The zebrafish miR-125c is induced under hypoxic stressOncotarget · 2017Article
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoblasts are a prerequisite for osteogenesis and bone formation, and play a key role in metabolic balance, growth, development and wound repair. G protein-coupled receptor kinase interacting protein 1 (GIT1) and a series of miRNAs are known to have important effects in the growth and migration of osteoblasts, but little is known about micro RNAs (miRNAs) targeting GIT1. The present study found that miR-125a-3p has matching sites on GIT1. In the osteoblastic differentiation process of human bone marrow-derived mesenchymal stem cells (HMSCs), the expression of miR-125a-3p was suppressed compared with that in non-differentiating (HMSCs) while the expression of GIT1 showed a gradual and significant increase. Thus, miR-125a-3p expression was negatively correlated with the expression of GIT1. Following the transfection of human osteoblasts with miR-125a-3p mimics and inhibitors, respectively, the effect on GIT1 expression was opposite to the change of miR-125a-3p expression. In addition, the impact of miR-125a-3p and GIT1 on osteoblastic proliferation and differentiation was detected, and the results indicated that miR-125a-3p targetedly regulated GIT1 expression to inhibit osteoblastic proliferation and differentiation. These findings may provide a theoretical basis for clarifying the physiological and pathological role of miRNAs in osteoblast differentiation and maturation processes, and for the physiological and pathological investigation of bone.
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