Evidence map›Paper›PMID 28101109›Full record

ArticleStem cells international2016

Isolation of an ES-Derived Cardiovascular Multipotent Cell Population Based on VE-Cadherin Promoter Activity.

Violetta A Maltabe, Eleonora Barka, Marianthi Kontonika, Dimitra Florou, Maria Kouvara-Pritsouli, Maria Roumpi, Simeon Agathopoulos, Theofilos M Kolettis, Panos Kouklis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 4 countries.

Violetta A MaltabeLaboratory of Biology, Medical School, University of Ioannina, Ioannina, Greece; Department of Biomedical Research, Institute of Molecular Biology & Biotechnology, Foundation of Research and Technology-Hellas, University Campus, 45110 Ioannina, Greece.
Eleonora BarkaCeramics and Composites Laboratory Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece.
Marianthi KontonikaDepartment of Cardiology, University of Ioannina Medical School, Ioannina, Greece; Cardiovascular Research Institute, Ioannina, Greece.
Dimitra FlorouLaboratory of Biology, Medical School, University of Ioannina, Ioannina, Greece.
Maria Kouvara-PritsouliLaboratory of Biology, Medical School, University of Ioannina, Ioannina, Greece.
Maria RoumpiCeramics and Composites Laboratory Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece.
Simeon AgathopoulosCeramics and Composites Laboratory Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece.
Theofilos M KolettisDepartment of Cardiology, University of Ioannina Medical School, Ioannina, Greece; Cardiovascular Research Institute, Ioannina, Greece.
Panos KouklisLaboratory of Biology, Medical School, University of Ioannina, Ioannina, Greece; Department of Biomedical Research, Institute of Molecular Biology & Biotechnology, Foundation of Research and Technology-Hellas, University Campus, 45110 Ioannina, Greece.ORCID 0000-0003-0378-5619
University of Ioannina · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Embryonic Stem (ES) or induced Pluripotent Stem (iPS) cells are important sources for cardiomyocyte generation, targeted for regenerative therapies. Several in vitro protocols are currently utilized for their differentiation, but the value of cell-based approaches remains unclear. Here, we characterized a cardiovascular progenitor population derived during ES differentiation, after selection based on VE-cadherin promoter (Pvec) activity. ESCs were genetically modified with an episomal vector, allowing the expression of puromycin resistance gene, under Pvec activity. Puromycin-surviving cells displayed cardiac and endothelial progenitor cells characteristics. Expansion and self-renewal of this cardiac and endothelial dual-progenitor population (CEDP) were achieved by Wnt/

Identifiers

PMID28101109
PMCPMC5215608
OpenAlexW2565381178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.