ArticleCase reports in dermatology
Remarkable Improvement of Nail Changes in Alopecia Areata Universalis with 10 Months of Treatment with Tofacitinib: A Case Report.
Article in Case reports in dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Treatments for alopecia areata: a network meta-analysis.The Cochrane database of systematic reviews · 2023Pooled it
- A phase 2a randomized vehicle-controlled multi-center study of the safety and efficacy of delgocitinib in subjects with moderate-to-severe alopecia areata.Archives of dermatological research · 2023Trial
- Effectiveness of Baricitinib on Nail Alopecia Areata: A 48-Week Single-Center Retrospective Study.Clinical drug investigation · 2026Article
- Dermoscopic Assessment of Nail Alterations in Egyptian Patients with Alopecia Areata.Dermatology practical & conceptual · 2026Article
- [Nail changes in inflammatory dermatoses: recognition and treatment].Dermatologie (Heidelberg, Germany) · 2025Review
- Alopecia Areata of the Nails: Diagnosis and Management.Journal of clinical medicine · 2024Review
- Therapeutic Response of Alopecia Areata-Associated Nail Changes to Baricitinib.Case reports in dermatological medicine · 2024Article
- A Comprehensive Literature Review of JAK Inhibitors in Treatment of Alopecia Areata.Clinical, cosmetic and investigational dermatology · 2021Review
- Scoping Review on the Use of Drugs Targeting JAK/STAT Pathway in Atopic Dermatitis, Vitiligo, and Alopecia Areata.Dermatology and therapy · 2019Article
- An excellent response to tofacitinib in a Brazilian adolescent patient with alopecia areata: A case report and a review of the literature.Clinical case reports · 2019Article
- JAK Inhibitors for Treatment of Alopecia Areata.The Journal of investigative dermatology · 2018Review
- Role of janus kinase inhibitors in the treatment of alopecia areata.Drug design, development and therapy · 2018Review
- The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm.Advances in therapy · 2017Review
- Recovery of nail dystrophy potential new therapeutic indication of tofacitinib.Clinical rheumatology · 2017Article
- Resistant Alopecia Areata Treated with Tofacitinib.International journal of trichologyArticle
- Clinico-Dermoscopic Pattern of Beard Alopecia Areata: A Cross-Sectional Study.Indian dermatology online journalArticle
- Tofacitinib for the Treatment of Twenty-Nail Dystrophy: A Single Case Report.Indian journal of dermatologyArticle
- Topical tofacitinib in treatment of alopecia areata.Einstein (Sao Paulo, Brazil)Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alopecia areata (AA) is a chronic, autoimmune disease. The main symptom is massive hair loss, localized or diffuse, in the scalp and the whole body. However, nails may also be involved, and brittleness, fragility and pitting can be signs of nail dystrophy in AA patients. Here, we report the case of a male patient with AA refractory to various treatments, including oral, topical and intralesional corticosteroids, immunosuppressants, cyclosporin and PUVA (oxoralen plus ultraviolet light), all interrupted due to side effects. The patient's nails had erythematous blotches (striated lunulae) with regular and superficial pitting as well as fragility (trachyonychia), and he could no longer play the guitar because of these symptoms. With patient consent, we introduced tofacitinib (5 mg twice daily), which resulted in remarkable improvements not only regarding hair regrowth but also nail changes, with function recovery within 10 months.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.