ArticleHypertension research : official journal of the Japanese Society of Hypertension2017
Reductions in central arterial compliance with age are related to sympathetic vasoconstrictor nerve activity in healthy men.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Impaired Windkessel function and proximal aortic stiffness: Linking vascular ageing to cognitive decline.Experimental physiology · 2025Review
- Regional cerebral pulsatile hemodynamics during isocapnic and poikilocapnic hyperthermia in young men.Physiological reports · 2025Article
- Sex differences in sympathetic activity and pulse wave velocity in adults with chronic kidney disease.American journal of physiology. Renal physiology · 2024Article
- Sports activities at a young age decrease hypertension risk-The J-FitPhysiological reports · 2022Article
- Relationships between muscle sympathetic nerve activity and novel indices of arterial stiffness using single oscillometric cuff in patients with hypertension.Physiological reports · 2022Article
- COVID-19 is getting on our nerves: sympathetic neural activity and haemodynamics in young adults recovering from SARS-CoV-2.The Journal of physiology · 2021Article
- Acute Effects of Short-Term Warm Water Immersion on Arterial Stiffness and Central Hemodynamics.Frontiers in physiology · 2021Article
- Elevated Muscle Sympathetic Nerve Activity Contributes to Central Artery Stiffness in Young and Middle-Age/Older Adults.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Central and peripheral blood pressure response to a single bout of an exercise session in patients with resistant hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Healthy aging and carotid performance: strain measures and β-stiffness index.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Proinflammatory Arterial Stiffness Syndrome: A Signature of Large Arterial Aging.Journal of vascular research · 2018Review
- Mechanisms and Subclinical Consequences of Aortic Stiffness.Hypertension (Dallas, Tex. : 1979) · 2017Review
- What is important for aging-induced arterial stiffening, autonomic dysfunction, vascular characteristics or both?Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
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Abstract
The compliance of large elastic arteries in the cardiothoracic circulation declines, whereas sympathetic nervous system activity increases markedly with advancing age in adult humans. We tested the hypothesis that the reduction in compliance of the large elastic arteries with age is associated with elevations in sympathetic tone to vascular smooth muscle in 16 young and 17 older adults. Carotid arterial compliance (via ultrasonography) was 45% lower in healthy older compared with young men (P<0.001), and was inversely related to sympathetic nerve activity (via microneurography) (r=-0.51; P<0.005). Statistically correcting for sympathetic nerve activity abolished the age-related difference in arterial compliance (P=0.35). Our results suggest that increases in the sympathetic tone of vascular smooth muscle may have a mechanistic role in the age-related reduction in large artery compliance.
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