ArticleScience translational medicine2017
Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma.
Open access · greenAbstract readClinical Trial, Phase I
In one paragraph
Article in Science translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 196 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
196citing papers in PubMed, 2 pooled it
16.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
196 citing papers in PubMed, 2 syntheses or guidelines pooled it, 321 citations in OpenAlex.
- Efficacy and safety of innate and adaptive immunotherapy combined with standard of care in high-grade gliomas: a systematic review and meta-analysis.Frontiers in immunology · 2023Pooled it
- The Future of Cancer Diagnosis, Treatment and Surveillance: A Systemic Review on Immunotherapy and Immuno-PET Radiotracers.Molecules (Basel, Switzerland) · 2021Pooled it
- Whole-body CD8Nature communications · 2025Trial
- Safety and antitumor activity of GD2-Specific 4SCAR-T cells in patients with glioblastoma.Molecular cancer · 2023Trial
- A PET reporter ligand for quantitative imaging of gene expression in the brain.Nature biomedical engineering · 2026Article
- ICOS-Targeted Peptide Imaging Informs Therapeutic Response of STING Agonist in Lung Adenocarcinoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Mapping Therapeutic Regulatory T Cell Fate with MRI: Current Strategies and Translational Outlook.Nanomaterials (Basel, Switzerland) · 2026Review
- Metabolic Glycoengineering Enables Fluorine-18 Radiolabeling of T Lymphocytes via Dual-Bioorthogonal Chemistry.Bioconjugate chemistry · 2026Article
- Dual-modality imaging enables longitudinal biodistribution profiling of intracerebroventricular CAR-T therapy in orthotopic glioma.Cancer immunology, immunotherapy : CII · 2026Article
- Cell therapy for brain tumors: The first 60 years.Cell reports. Medicine · 2026Review
- Imaging CRISPR-edited CAR-T cell therapies with optical and positron emission tomography reporters.Theranostics · 2026Article
- Retargeted oncolytic viruses engineered to remodel the tumor microenvironment for glioblastoma immunotherapy.Nature cancer · 2025Article
- Small-molecule control of CAR T cells.Nature reviews. Chemistry · 2025Review
- Practical considerations for clinical translation of PET imaging of adoptive cell therapies.Npj imaging · 2025Review
- Longitudinal imaging of therapeutic enzyme expression after gene therapy for Fabry disease using positron emission tomography and the radiotracer [Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Recent developments in translational imaging of in vivo gene therapy outcomes.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- Approaches to Imaging Immune Activation Using PET.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Review
- Efficient radiolabeling of mesoporous silica nanoparticles for single-cell PET imaging.European journal of nuclear medicine and molecular imaging · 2025Article
- Challenges in the preclinical design and assessment of CAR-T cells.Frontiers in immunology · 2025Review
- CAR T-cells for pediatric solid tumors: where to go from here?Cancer metastasis reviews · 2024Review
136 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 1 country.
Khun Visith Keu *Department of Radiology, Molecular Imaging Program, Stanford University, Palo Alto, CA, 94305, United States.
Timothy H Witney *Department of Radiology, Molecular Imaging Program, Stanford University, Palo Alto, CA, 94305, United States.
Shahriar Yaghoubi *Department of Radiology, Molecular Imaging Program, Stanford University, Palo Alto, CA, 94305, United States.
Jarrett RosenbergDepartment of Radiology, Molecular Imaging Program, Stanford University, Palo Alto, CA, 94305, United States.
Anita KurienNeurosurgery, City of Hope, Duarte, CA, 91010, United States.
Rachel MagnussonNeurosurgery, City of Hope, Duarte, CA, 91010, United States.
John WilliamsMolecular & Medical Pharmacology, UCLA, Los Angeles, CA, 90095, United States.
Frezghi HabteDepartment of Radiology, Molecular Imaging Program, Stanford University, Palo Alto, CA, 94305, United States.
Jamie R WagnerHematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, 91010, United States.
Stephen FormanHematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, 91010, United States.
Christine BrownHematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, 91010, United States.
Martin Allen-AuerbachMolecular & Medical Pharmacology, UCLA, Los Angeles, CA, 90095, United States.
Johannes CzerninMolecular & Medical Pharmacology, UCLA, Los Angeles, CA, 90095, United States.
Winson TangSangamo BioSciences Inc, Richmond, CA 94804, United States.
Michael C JensenBen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, Washington, 98145, United States.
Behnam BadieNeurosurgery, City of Hope, Duarte, CA, 91010, United States.
Sanjiv S GambhirDepartment of Radiology, Molecular Imaging Program, Stanford University, Palo Alto, CA, 94305, United States.
City of Hope · USUniversity of California, Los Angeles · USSangamo BioSciences (United States) · US
Funding
Small Animal ImagingP50CA114747 · NCI · STANFORD UNIVERSITY · PI RAO, JIANGHONG · 2005 to 2014
$18.2MReporter Imaging of Protein-Protein InteractionsR01CA082214 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GAMBHIR, SANJIV S · 1999 to 2019
$5.9MRole of Receptor for Advanced Glycation End Product (RAGE) Pathway in Brain TumorsR01CA155769 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI BADIE, BEHNAM · 2011 to 2021
$3.8MImaging Cytolytic T Cells in Cancer Patients Using PET Reporter Genes/Reporter PrR01CA135486 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2008 to 2012
$1.3MDynamic Magnetic Targeting of Activated Brain Macrophages for Glioma TherapyR21NS081594 · NINDS · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI BADIE, BEHNAM, BERLIN, JACOB M · 2013 to 2014
$465kNovel Cell Delivery Method for Brain Tumor TherapyR21CA189223 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI BADIE, BEHNAM · 2014 to 2015
$414kNCI NIH HHS P50 CA114747NCI NIH HHS R01 CA082214NCI NIH HHS R01 CA135486NCI NIH HHS R01 CA155769NCI NIH HHS R21 CA189223NINDS NIH HHS R21 NS081594Wellcome TrustWellcome Trust 107610/Z/15/Z
Abstract
High-grade gliomas are aggressive cancers that often become rapidly fatal. Immunotherapy using CD8
Indexed as
Genes, ReporterAgedBrain NeoplasmsFemaleGene ExpressionGenetic TherapyGliomaHumansImmunotherapyInterleukin-13MaleMiddle AgedNeoplasm Recurrence, LocalPositron-Emission TomographyProspective StudiesReceptors, Antigen, T-CellIL13 protein, humanInterleukin-13Receptors, Antigen, T-CellThymidine Kinase
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.