Evidence map›Paper›PMID 28100772›Full record

ArticleThe Journal of biological chemistry2017

Aikaterini Alexaki, Benjamin A Clarke, Oksana Gavrilova, Yinyan Ma, Hongling Zhu, Xinran Ma, Lingyan Xu, Galina Tuymetova, Bridget C Larman, Maria L Allende and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
  2. Article
  3. Effect ofWorld journal of diabetes · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. ORMDL in metabolic health and disease.Pharmacology & therapeutics · 2023
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Contribution of specific ceramides to obesity-associated metabolic diseases.Cellular and molecular life sciences : CMLS · 2022
    Review
  13. You aren't IMMUNE to the ceramides that accumulate in cardiometabolic disease.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2022
    Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Ceramides in Metabolism: Key Lipotoxic Players.Annual review of physiology · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Aikaterini AlexakiFrom the Genetics of Development and Disease Branch and.
Benjamin A ClarkeFrom the Genetics of Development and Disease Branch and.
Oksana GavrilovaMouse Metabolism Core Laboratory, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 and.
Yinyan MaMouse Metabolism Core Laboratory, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 and.
Hongling ZhuFrom the Genetics of Development and Disease Branch and.
Xinran MaFrom the Genetics of Development and Disease Branch and.
Lingyan XuFrom the Genetics of Development and Disease Branch and.
Galina TuymetovaFrom the Genetics of Development and Disease Branch and.
Bridget C LarmanFrom the Genetics of Development and Disease Branch and.
Maria L AllendeFrom the Genetics of Development and Disease Branch and.
Teresa M Dunnthe Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20184.
Richard L ProiaFrom the Genetics of Development and Disease Branch and proia@nih.gov.
National Institute of Diabetes and Digestive and Kidney Diseases · USNational Institutes of Health · USUniformed Services University of the Health Sciences · US

Funding

Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND N. DUBOIS · 2009 to 2026
$42.7M
THE ROLE OF LACTOSYLCERAMIDE IN RENAL AGING AND DISEASEP20RR017677 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MAO, CUNGUI · 2002 to 2011
$23.4M
Metabolic Studies of Mouse Models of Obesity and DiabetesZICDK070002 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GAVRILOVA, OKSANA · 2009 to 2025
$15.0M
Mouse Models of Novel Sphingolipid Biology and Disease MechanismsZIADK056014 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI PROIA, RICHARD · 2009 to 2025
$10.6M
Sphingolipid Biology and Regulation of MetabolismZIADK056018 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI PROIA, RICHARD · 2009 to 2022
$8.9M
Sphingolipid Biology of Inflammation and ImmunityZIADK056015 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI PROIA, RICHARD · 2009 to 2021
$7.9M
NCI NIH HHS P30 CA138313NCRR NIH HHS P20 RR017677
6 · The paper itself

Abstract

Sphingolipids are a diverse class of essential cellular lipids that function as structural membrane components and as signaling molecules. Cells acquire sphingolipids by both

Indexed as

HomeostasisAdipocytesAdiposityAnimalsCell DifferentiationCell SurvivalGene DeletionInflammationInsulin ResistanceLipid MetabolismLipogenesisMacrophagesMiceMice, KnockoutSerine C-PalmitoyltransferaseSphingolipidsSerine C-PalmitoyltransferaseSphingolipidsSptlc1 protein, mouseadipocyteinflammationlipodystrophyserine palmitoyltransferasesphingolipid

Identifiers

PMID28100772
PMCPMC5339773
OpenAlexW2571707190

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.