ArticleNeurology2017
Direct cortical stimulation of human posteromedial cortex.
Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04748146 (CAUSAL MECHANISMS OF DISTRIBUTED BRAIN NETWORK FUNCTION DURING EPISODIC MEMORY RETRIEVAL), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Causal mechanisms of distributed brain network function during episodic memory retrieval
Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Causal Mapping of Bodily Awareness and Mesoscale Circuit Organization in the Human Cingulate and Precuneus.Research square · 2026Article
- Creativity and its link to epilepsy.Epilepsia open · 2024Review
- Default mode network electrophysiological dynamics and causal role in creative thinking.Brain : a journal of neurology · 2024Article
- Cortical sites critical to language function act as connectors between language subnetworks.Nature communications · 2024Article
- A tripartite view of the posterior cingulate cortex.Nature reviews. Neuroscience · 2023Review
- Review
- Towards causal mechanisms of consciousness through focused transcranial brain stimulation.Neuroscience of consciousness · 2023Review
- Age-dependent vestibular cingulate-cerebral network underlying gravitational perception: a cross-sectional multimodal study.Brain informatics · 2022Article
- The Temporal Lobe as a Symptomatogenic Zone in Medial Parietal Lobe Epilepsy.Frontiers in neurology · 2022Review
- Altered sense of self during seizures in the posteromedial cortex.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Does the Prefrontal Cortex Play an Essential Role in Consciousness? Insights from Intracranial Electrical Stimulation of the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Insights into human cognition from intracranial EEG: A review of audition, memory, internal cognition, and causality.Journal of neural engineering · 2020Review
- Deep posteromedial cortical rhythm in dissociation.Nature · 2020Article
- Intrinsic network architecture predicts the effects elicited by intracranial electrical stimulation of the human brain.Nature human behaviour · 2020Article
- Visual Organization of the Default Network.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Stimulation of the Posterior Cingulate Cortex Impairs Episodic Memory Encoding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Intensity of affective experience is modulated by magnitude of intracranial electrical stimulation in human orbitofrontal, cingulate and insular cortices.Social cognitive and affective neuroscience · 2019Article
- Functional control of electrophysiological network architecture using direct neurostimulation in humans.Network neuroscience (Cambridge, Mass.) · 2019Article
- Direct Cortical Recordings Suggest Temporal Order of Task-Evoked Responses in Human Dorsal Attention and Default Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Changes in subjective experience elicited by direct stimulation of the human orbitofrontal cortex.Neurology · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe posteromedial cortex (PMC) is a collective term for an anatomically heterogeneous area of the brain constituting a core node of the human default mode network (DMN), which is engaged during internally focused subjective cognition such as autobiographical memory.
methodsWe explored the effects of causal perturbations of PMC with direct electric brain stimulation (EBS) during presurgical epilepsy monitoring with intracranial EEG electrodes.
resultsData were collected from 885 stimulations in 25 patients implanted with intracranial electrodes across the PMC. While EBS of regions immediately dorsal or ventral to the PMC reliably produced somatomotor or visual effects, respectively, we found no observable behavioral or subjectively reported effects when sites within the boundaries of PMC were electrically perturbed. In each patient, null effects of PMC stimulation were observed for sites in which intracranial recordings had clearly demonstrated electrophysiologic responses during autobiographical recall.
conclusionsDirect electric modulation of the human PMC produced null effects when standard functional mapping methods were used. More sophisticated stimulation paradigms (e.g., EBS during experimental cognitive tests) will be required for testing the causal contribution of PMC to human cognition and subjective experience. Nonetheless, our findings suggest that some extant theories of PMC and DMN contribution to human awareness and subjective conscious states require cautious re-examination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.