Evidence map›Paper›PMID 28100677›Full record

ArticleThe EMBO journal2017

Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen.

Flavio Schwarz, Corinna S Landig, Shoib Siddiqui, Ismael Secundino, Joshua Olson, Nissi Varki, Victor Nizet, Ajit Varki

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 80 citations in OpenAlex.

  1. Sialylation in the nervous system: Functions and mechanisms.The Journal of biological chemistry · 2026
    Review
  2. Review
  3. Neutrophil CEACAMs and the Inflammatory Response toJournal of innate immunity · 2026
    Review
  4. Review
  5. Siglecs: From Biomodulation to Immunotherapy.Current protein & peptide science · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. The new progress in cancer immunotherapy.Clinical and experimental medicine · 2023
    Review
  14. Proinflammatory Macrophage Activation by the Polysialic Acid-Siglec-16 Axis Is Linked to Increased Survival of Patients with Glioblastoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
  15. Review
  16. Review
  17. Review
  18. Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Flavio SchwarzGlycobiology Research and Training Center, University of California, San Diego, La Jolla, CA, USA.
Corinna S LandigGlycobiology Research and Training Center, University of California, San Diego, La Jolla, CA, USA.
Shoib SiddiquiGlycobiology Research and Training Center, University of California, San Diego, La Jolla, CA, USA.
Ismael SecundinoGlycobiology Research and Training Center, University of California, San Diego, La Jolla, CA, USA.
Joshua OlsonDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Nissi VarkiGlycobiology Research and Training Center, University of California, San Diego, La Jolla, CA, USA.
Victor NizetGlycobiology Research and Training Center, University of California, San Diego, La Jolla, CA, USA vnizet@ucsd.edu a1varki@ucsd.edu.ORCID 0000-0003-3847-0422
Ajit VarkiGlycobiology Research and Training Center, University of California, San Diego, La Jolla, CA, USA vnizet@ucsd.edu a1varki@ucsd.edu.ORCID 0000-0002-2206-975X
University of California San Diego · US

Funding

Siglec Modulation of Inflammatory ResponsesP01HL107150 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LE, DZUNG T · 2011 to 2017
$18.0M
BIOSYNTHESIS AND REGULATION OF SUBSTITUTED SIALIC ACIDSR01GM032373 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VARKI, AJIT P · 1985 to 2022
$6.9M
NHLBI NIH HHS P01 HL107150NIGMS NIH HHS R01 GM032373
6 · The paper itself

Abstract

Paired immune receptors display near-identical extracellular ligand-binding regions but have intracellular sequences with opposing signaling functions. While inhibitory receptors dampen cellular activation by recognizing self-associated molecules, the functions of activating counterparts are less clear. Here, we studied the inhibitory receptor Siglec-11 that shows uniquely human expression in brain microglia and engages endogenous polysialic acid to suppress inflammation. We demonstrated that the human-specific pathogen

Indexed as

AnimalsCytokinesEscherichia coliEscherichia coli InfectionsHumansImmune EvasionInflammationLectinsMacrophagesMembrane ProteinsMiceMice, TransgenicMicrobial ViabilitySialic Acid Binding Immunoglobulin-like LectinsSialic AcidsCytokinesLectinsMembrane Proteinspolysialic acidSialic Acid Binding Immunoglobulin-like LectinsSialic AcidsSIGLEC11 protein, humanSIGLEC16 protein, humanEscherichia coli K1molecular mimicrypaired receptorspolysialic acidSiglec

Identifiers

PMID28100677
PMCPMC5350563
OpenAlexW2571762203

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.