Evidence map›Paper›PMID 28100666›Full record

ArticleOpen biology2017

T-type Ca2+ channels are required for enhanced sympathetic axon growth by TNFα reverse signalling.

Lilian Kisiswa, Clara Erice, Laurent Ferron, Sean Wyatt, Catarina Osório, Annette C Dolphin, Alun M Davies

Open access · goldAbstract read
In one paragraph

Article in Open biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. How CD40L reverse signaling regulates axon and dendrite growth.Cellular and molecular life sciences : CMLS · 2021
    Article
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  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lilian KisiswaSchool Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.
Clara EriceSchool Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.
Laurent FerronDepartment of Neuroscience, Physiology and Pharmacology, University College London, Andrew Huxley Building, Gower Street, London WC1E 6BT, UK.
Sean WyattSchool Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.
Catarina OsórioSchool Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.
Annette C DolphinDepartment of Neuroscience, Physiology and Pharmacology, University College London, Andrew Huxley Building, Gower Street, London WC1E 6BT, UK.
Alun M DaviesSchool Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK daviesalun@cf.ac.uk.ORCID 0000-0001-5841-8176
Cardiff University · GBUniversity College London · GB

Funding

Wellcome Trust 098360/Z/12/ZWellcome Trust 103852/Z/14/Z
6 · The paper itself

Abstract

Tumour necrosis factor receptor 1 (TNFR1)-activated TNFα reverse signalling, in which membrane-integrated TNFα functions as a receptor for TNFR1, enhances axon growth from developing sympathetic neurons and plays a crucial role in establishing sympathetic innervation. Here, we have investigated the link between TNFα reverse signalling and axon growth in cultured sympathetic neurons. TNFR1-activated TNFα reverse signalling promotes Ca

Indexed as

Action PotentialsAnimalsAxonsCalcium Channels, T-TypeCells, CulturedMiceNeuronsProtein Kinase CReceptors, Tumor Necrosis Factor, Type ISignal TransductionTumor Necrosis Factor-alphaCalcium Channels, T-TypeProtein Kinase CReceptors, Tumor Necrosis Factor, Type ITnfrsf1a protein, mouseTumor Necrosis Factor-alphaaxon growthCa2+ channelsdevelopmentreverse signallingsympathetic neuronTNFα

Identifiers

PMID28100666
PMCPMC5303278
OpenAlexW2574615302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.