Evidence map›Paper›PMID 28100629›Full record

Trial reportEuropean journal of endocrinology2017

Impact of food, alcohol and pH on modified-release hydrocortisone developed to treat congenital adrenal hyperplasia.

Nayananjani Karunasena, Daniel N Margetson, Greg Neal, Martin J Whitaker, Richard Jm Ross

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Novel treatments for congenital adrenal hyperplasia.Reviews in endocrine & metabolic disorders · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Nayananjani KarunasenaDepartment of Oncology and MetabolismUniversity of Sheffield, Sheffield, UK.
Daniel N MargetsonDiurnal LimitedCardiff, UK.
Greg NealDiurnal LimitedCardiff, UK.
Martin J WhitakerDiurnal LimitedCardiff, UK.
Richard Jm RossDepartment of Oncology and MetabolismUniversity of Sheffield, Sheffield, UK.
Diurnal (United Kingdom) · GBUniversity of Sheffield · GBBarnardo's · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe developed a modified-release hydrocortisone, Chronocort, to replace the cortisol rhythm in patients with congenital adrenal hyperplasia. Food, alcohol and pH affect drug absorption, and it is important to assess their impact when replicating a physiological rhythm. SUBJECTS AND

methods

results

conclusionsGastric pH ≤6.0 and alcohol do not affect hydrocortisone release from Chronocort. Food delays Chronocort absorption, but cortisol exposure is similar in the fasted and fed state and exposure as assessed by free cortisol is similar between Chronocort and immediate-release hydrocortisone.

Indexed as

FoodAdrenal Hyperplasia, CongenitalAdultAnti-Inflammatory AgentsCross-Over StudiesEthanolFemaleHumansHydrocortisoneHydrogen-Ion ConcentrationMaleAnti-Inflammatory AgentsEthanolHydrocortisone

Identifiers

PMID28100629
PMCPMC5425936
OpenAlexW2572293220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.