Evidence map›Paper›PMID 28100623›Full record

ArticleJournal of virology2017

A Temperature-Sensitive Lesion in the N-Terminal Domain of the Rotavirus Polymerase Affects Its Intracellular Localization and Enzymatic Activity.

Allison O McKell, Leslie E W LaConte, Sarah M McDonald

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Understanding the penetrance of intrinsic protein disorder in rotavirus proteome.International journal of biological macromolecules · 2020
    Article
  6. Journal of virology · 2019
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Allison O McKellVirginia Tech Carilion School of Medicine and Research Institute, Roanoke, Virginia, USA.
Leslie E W LaConteVirginia Tech Carilion School of Medicine and Research Institute, Roanoke, Virginia, USA.
Sarah M McDonaldVirginia Tech Carilion School of Medicine and Research Institute, Roanoke, Virginia, USA mcdonaldsa@vtc.vt.edu.
Carilion Clinic · USVirginia–Maryland College of Veterinary Medicine · USVirginia Tech · US

Funding

Rotavirus Genome Replication and Virion AssemblyR01AI116815 · NIAID · WAKE FOREST UNIVERSITY · PI Sarah Marie McDonald Esstman · 2015 to 2026
$3.7M
Allosteric regulation of a viral RNA-dependent RNA polymeraseR21AI119588 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI MCDONALD ESSTMAN, SARAH MARIE · 2015 to 2016
$443k
NIAID NIH HHS R01 AI116815NIAID NIH HHS R21 AI119588
6 · The paper itself

Abstract

Temperature-sensitive (

Indexed as

Amino Acid SequenceAnimalsChlorocebus aethiopsCOS CellsEnzyme StabilityMolecular Dynamics SimulationMutation, MissenseProtein BindingProtein DomainsProtein TransportRotavirusTemperatureViral Core ProteinsViral Core ProteinsVP1 protein, RotaviruspolymeraseRNA synthesisrotavirustemperature-sensitive mutantviroplasmVP1

Identifiers

PMID28100623
PMCPMC5355613
OpenAlexW2573335121

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.