Evidence map›Paper›PMID 28100587›Full record

ArticleGenetics2017

Efficient Estimation of Realized Kinship from Single Nucleotide Polymorphism Genotypes.

Bowen Wang, Serge Sverdlov, Elizabeth Thompson

Abstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Genomic selection for agronomic traits in a winter wheat breeding program.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Robust fingerprinting of genomic databases.Bioinformatics (Oxford, England) · 2022
    Article
  12. Population Structure and Relatedness for Genome-Wide Association Studies.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bowen WangDepartment of Statistics, University of Washington, Seattle, Washington 98195-4322.
Serge SverdlovDepartment of Statistics, University of Washington, Seattle, Washington 98195-4322.
Elizabeth ThompsonDepartment of Statistics, University of Washington, Seattle, Washington 98195-4322 eathomp@uw.edu.

Funding

Statistical Methods for X-Chromosome Genetic DataP01GM099568 · NIGMS · UNIVERSITY OF WASHINGTON · PI WEIR, BRUCE S. · 2012 to 2016
$7.3M
Methods for the Genetic Epidemiology of Complex TraitsR37GM046255 · NIGMS · UNIVERSITY OF WASHINGTON · PI THOMPSON, ELIZABETH ALISON · 2008 to 2017
$4.2M
NIGMS NIH HHS P01 GM099568NIGMS NIH HHS R37 GM046255
6 · The paper itself

Abstract

Realized kinship is a key statistic in analyses of genetic data involving relatedness of individuals or structure of populations. There are several estimators of kinship that make use of dense SNP genotypes. We introduce a class of estimators, of which some existing estimators are special cases. Within this class, we derive properties of the estimators and determine an optimal estimator. Additionally, we introduce an alternative marker weighting that takes allelic associations [linkage disequilibrium (LD)] into account, and apply this weighting to several estimators. In a simulation study, we show that improved estimators are obtained (1) by optimal weighting of markers, (2) by taking physical contiguity of genome into account, and (3) by weighting on the basis of LD.

Indexed as

AlgorithmsGenotypePedigreePolymorphism, Single NucleotideAnimalsGenome-Wide Association StudyHumansLinkage DisequilibriumModels, Geneticgenomic relationship matrix (GRM)linkage disequilibriumlocal identity by descent (IBD)locus weightingrealized kinship

Identifiers

PMID28100587
PMCPMC5340323

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.