Evidence map›Paper›PMID 28100530›Full record

ArticleBritish journal of anaesthesia2017

Feasibility of measuring memory response to increasing dexmedetomidine sedation in children.

K P Mason, E R Kelhoffer, R Prescilla, M Mehta, J C Root, V J Young, F Robinson, R A Veselis

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of anaesthesia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

K P MasonDepartment of Anesthesia, Harvard Medical School, Boston Children's Hospital, Boston, MA, USA keira.mason@childrens.harvard.edu.
E R KelhofferDepartment of Anesthesiology and Critical Care, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
R PrescillaDepartment of Anaesthesiology, Perioperative and Pain Medicine, Harvard Medical School, MA, USA.
M MehtaDepartment of Anesthesiology and Critical Care, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
J C RootDepartment of Anesthesiology and Critical Care, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
V J YoungDepartment of Anesthesia, Harvard Medical School, Boston Children's Hospital, Boston, MA, USA.
F RobinsonDM-Stat, Inc, Malden, MA, USA.
R A VeselisDepartment of Anesthesiology and Critical Care, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Memorial Sloan Kettering Cancer Center · USBoston Children's Hospital · USDM-STAT (United States) · USHarvard University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundThe memory effect of dexmedetomidine has not been prospectively evaluated in children. We evaluated the feasibility of measuring memory and sedation responses in children during dexmedetomidine sedation for non-painful radiological imaging studies. Secondarily, we quantified changes in memory in relation to the onset of sedation.

methodsA 10 min bolus of dexmedetomidine (2 mcg kg

resultsOf 64 accruals, 30 children (mean [SD]6.1 (1.2) yr, eight male) received dexmedetomidine and completed all study tasks. Individual responses were able to be modelled successfully in the 30 children completing all the study tasks, demonstrating feasibility of this approach. Children had 50% probability of verbal response at five min 40 s after infusion start, whereas 50% probability of subsequent recognition memory occurred sooner at four min five s.

conclusionsQuantifying memory and sedation effects during dexmedetomidine infusion in verbal children was possible and demonstrated that memory function was present until shortly before verbal unresponsiveness occurred. This is the first study to investigate the effect of dexmedetomidine on memory in children. CLINICAL

trial registrationNCT 02354378.

Indexed as

ChildChild, PreschoolDexmedetomidineFeasibility StudiesFemaleHumansHypnotics and SedativesMaleMemoryDexmedetomidineHypnotics and Sedativeschildconscious sedationdexmedetomidinememory

Identifiers

PMID28100530
PMCPMC5242243
OpenAlexW2575725641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.