Evidence map›Paper›PMID 28100496›Full record

Observational studyClinical and vaccine immunology : CVI2017

Preexisting Immunity, Not Frailty Phenotype, Predicts Influenza Postvaccination Titers among Older Veterans.

Puja Van Epps, Terrence Tumpey, Melissa B Pearce, Hana Golding, Patricia Higgins, Thomas Hornick, Christopher Burant, Brigid M Wilson, Richard Banks, Stefan Gravenstein and 1 more

Open access · diamondAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical and vaccine immunology : CVI, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 30 citations in OpenAlex.

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  18. Mechanisms underlying T cell ageing.Nature reviews. Immunology · 2019
    Review
  19. The Burden of Frailty Among U.S. Veterans and Its Association With Mortality, 2002-2012.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Puja Van EppsGeriatric Research, Education, and Clinical Center, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA puja.vanepps@va.gov.
Terrence TumpeyInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Melissa B PearceInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Hana GoldingDivision of Viral Products, Center for Biologics Evaluation & Research (CBER), FDA, Silver Spring, Maryland, USA.
Patricia HigginsGeriatric Research, Education, and Clinical Center, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA.
Thomas HornickGeriatric Research, Education, and Clinical Center, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA.
Christopher BurantGeriatric Research, Education, and Clinical Center, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA.
Brigid M WilsonGeriatric Research, Education, and Clinical Center, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA.
Richard BanksGeriatric Research, Education, and Clinical Center, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA.
Stefan GravensteinDivision of Geriatrics, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
David H CanadayGeriatric Research, Education, and Clinical Center, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA.
Case Western Reserve University · USLouis Stokes Cleveland VA Medical Center · USNational Center for Immunization and Respiratory Diseases · USCenter for Biologics Evaluation and Research · USCenters for Disease Control and Prevention · USGeriatric Research Education and Clinical Center · US

Funding

CD4+ T and B cell mechanisms of influenza vaccine non-responsiveness in older aduR01AI108972 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BETTS, MICHAEL R, CANADAY, DAVID H · 2014 to 2018
$2.5M
NIAID NIH HHS R01 AI108972
6 · The paper itself

Abstract

Both preexisting immunity to influenza and age have been shown to be correlates of influenza vaccine responses. Frailty, an indicator of functional impairment in older adults, was also shown in one study to predict lower influenza vaccine responses among nonveterans. In the current study, we aimed to determine the associations between frailty, preexisting immunity, and immune responses to influenza vaccine among older veterans. We studied 117 subjects (age range, 62 to 95 years [median age, 81 years]), divided into three cohorts based on the Fried frailty test, i.e., nonfrail (NF) (

Indexed as

AgedAged, 80 and overAntibodies, ViralFemaleHemagglutination Inhibition TestsHumansInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza B virusInfluenza, HumanInfluenza VaccinesMaleMiddle AgedNeutralization TestsVaccines, InactivatedVeteransAntibodies, ViralInfluenza VaccinesVaccines, InactivatedFrailtyinfluenza vaccines

Identifiers

PMID28100496
PMCPMC5339642
OpenAlexW2572420749

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.